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    Ttc4 tetratricopeptide repeat domain 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc4provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 4provided by RGD
    Primary source
    RGD:1308529
    See related
    EnsemblRapid:ENSRNOG00000042467 AllianceGenome:RGD:1308529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Hsp70 protein binding activity and Hsp90 protein binding activity. Predicted to be involved in defense response to virus; innate immune response; and protein folding. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human TTC4 (tetratricopeptide repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 56.0), Heart (RPKM 53.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttc4 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (126673535..126691203, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (121444712..121462381, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (126264758..126282431, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102944 Neighboring gene tetratricopeptide repeat domain 22 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene maestro heat-like repeat family member 7 Neighboring gene family with sequence similarity 151, member A Neighboring gene acyl-CoA thioesterase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear transport of protein TTC4 depends on the cell cycle. Dmitriev RI, et al. Cell Tissue Res, 2009 Jun. PMID 19390865
    2. The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. Crevel G, et al. PLoS One, 2008 Mar 5. PMID 18320024, Free PMC Article
    3. Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity. Shang J, et al. Proteomics, 2018 Jan. PMID 29251827
    4. Characterization of hampin/MSL1 as a node in the nuclear interactome. Dmitriev RI, et al. Biochem Biophys Res Commun, 2007 Apr 20. PMID 17335777, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395043.1 → NP_001381972.1  tetratricopeptide repeat protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A140UHY1, A0A8I5ZKD6
      Related
      ENSRNOP00000010229.6, ENSRNOT00000010229.8
      Conserved Domains (3) summary
      TIGR00990
      Location:76 → 218
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:79 → 107
      TPR; TPR repeat [structural motif]
      pfam18972
      Location:275 → 354
      Wheel; Cns1/TTC4 Wheel domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      126673535..126691203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110294.2 → XP_038966222.1  tetratricopeptide repeat protein 4 isoform X1

      UniProtKB/TrEMBL
      A6JYN7
      Related
      ENSRNOP00000102727.1, ENSRNOT00000143239.1
      Conserved Domains (3) summary
      TIGR00990
      Location:74 → 216
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:77 → 105
      TPR; TPR repeat [structural motif]
      pfam18972
      Location:273 → 352
      Wheel; Cns1/TTC4 Wheel domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013214.1: Suppressed sequence

      Description
      NM_001013214.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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