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    Ufc1 ubiquitin-fold modifier conjugating enzyme 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 445268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ufc1provided by RGD
    Official Full Name
    ubiquitin-fold modifier conjugating enzyme 1provided by RGD
    Primary source
    RGD:1303313
    See related
    EnsemblRapid:ENSRNOG00000003706 AllianceGenome:RGD:1303313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ufc1-s
    Summary
    Predicted to enable UFM1 conjugating enzyme activity. Predicted to be involved in several processes, including protein K69-linked ufmylation; regulation of type II interferon production; and reticulophagy. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 488.4), Liver (RPKM 461.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ufc1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86241779..86280513, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83709329..83719762, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89661763..89668513, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin specific peptidase 21 Neighboring gene G protein subunit gamma 5, pseudogene 1 Neighboring gene death effector domain-containing Neighboring gene nitrilase 1 Neighboring gene prefoldin subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development. Nahorski MS, et al. Brain, 2018 Jul 1. PMID 29868776, Free PMC Article
    2. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. Komatsu M, et al. EMBO J, 2004 May 5. PMID 15071506, Free PMC Article
    3. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Yoo HM, et al. Mol Cell, 2014 Oct 23. PMID 25219498
    4. Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. Zhang Y, et al. PLoS One, 2012. PMID 23152784, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105791

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UFM1 conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UFM1 conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UFM1 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K69-linked ufmylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K69-linked ufmylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ufmylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reticulophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reticulophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-fold modifier-conjugating enzyme 1
    Names
    Ufm1-conjugating enzyme 1-
    ufm1-conjugating enzyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003709.3 → NP_001003709.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 1

      See identical proteins and their annotated locations for NP_001003709.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6BBI8
      UniProtKB/TrEMBL
      A6JFW9
      Related
      ENSRNOP00000004938.3, ENSRNOT00000004938.7
      Conserved Domains (1) summary
      pfam08694
      Location:6 → 160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    2. NM_001429935.1 → NP_001416864.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6BBI8
      UniProtKB/TrEMBL
      A6JFW9

    3. NM_001429936.1 → NP_001416865.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q6BBI8
      UniProtKB/TrEMBL
      A6JFW9

    4. NM_001429937.1 → NP_001416866.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JFX1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86241779..86280513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090960.2 → XP_038946888.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6BBI8
      UniProtKB/TrEMBL
      A6JFW9
      Conserved Domains (1) summary
      pfam08694
      Location:6 → 160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

    2. XM_063272529.1 → XP_063128599.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

    3. XM_006250251.4 → XP_006250313.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

      Conserved Domains (1) summary
      pfam08694
      Location:6 → 160
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6BBI8.1 GenPept UniProtKB/Swiss-Prot:Q6BBI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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