Sh3bgrl1 SH3 domain binding glutamate rich protein like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3bgrl1provided by RGD
Official Full Name: SH3 domain binding glutamate rich protein like 1provided by RGD
Primary source: RGD:1560520
See related: AllianceGenome:RGD:1560520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sh3bgrl; RGD1560520
Summary: Predicted to enable protein-RNA adaptor activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of cytoplasmic translational initiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human SH3BGRL (SH3 domain binding glutamate rich protein like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 734.8), Adrenal (RPKM 601.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (78242704..78343633)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (74167029..74263783)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (80213209..80312393)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables protein-RNA adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH3 domain-binding glutamic acid-rich-like protein

Names: SH3 domain binding glutamate-rich protein like; SH3 domain binding glutamic acid-rich protein like; SH3-binding domain glutamic acid-rich protein like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173339.1 → NP_001166810.1 SH3 domain-binding glutamic acid-rich-like protein

See identical proteins and their annotated locations for NP_001166810.1

Status: VALIDATED

Source sequence(s)

BC169023, EV766621

UniProtKB/TrEMBL

B5DFD8

Conserved Domains (1) summary

cd03030
Location:2 → 97

GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...