Bpifa2 BPI fold containing family A, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bpifa2provided by RGD
Official Full Name: BPI fold containing family A, member 2provided by RGD
Primary source: RGD:3431
See related: EnsemblRapid:ENSRNOG00000013540 AllianceGenome:RGD:3431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Psp; Bpifa2e
Summary: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in defense response to bacterium. Located in secretory granule. Orthologous to human BPIFA2 (BPI fold containing family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (162953538..162961497)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (142493379..142501343)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (149492612..149501614)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that at least two pathways--granular and vesicular--are responsible for the generation of the two peptides, PSPFr-A and PSPFr-B, from rat parotid secretory protein.
Title: RP-HPLC-ESI-MS characterization of novel peptide fragments related to rat parotid secretory protein in parasympathetic induced saliva.
Increased parotid secretory protein was detected in sera of isoproterenol-treated animals, suggesting increased routing of the regulated secretory proteins to the basolateral pathway.
Title: Isoproterenol increases sorting of parotid gland cargo proteins to the basolateral pathway.
PSP co-fractionates with chromogranin A but not with secreted alkaline phosphatase; its sorting is not cell-type specific but the precise mechanism of its sorting is unknown
Title: Sorting of an exocrine secretory protein to the regulated secretory pathway in endocrine cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142217 (e-PCR)
- UniSTS:231467

D3Wox37 (e-PCR)
- UniSTS:518779

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BPI fold-containing family A member 2

Names: BPI fold containing family A, member 2E; neonatal submandibular gland protein; parotid secretory protein; short palate, lung and nasal epithelium carcinoma-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052808.1 → NP_434695.1 BPI fold-containing family A member 2 precursor

See identical proteins and their annotated locations for NP_434695.1

Status: PROVISIONAL

Source sequence(s)

M83209

UniProtKB/Swiss-Prot

Q63471

UniProtKB/TrEMBL

A6KHX3

Related

ENSRNOP00000018226.1, ENSRNOT00000018226.4

Conserved Domains (1) summary

pfam01273
Location:45 → 214

LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

162953538..162961497

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105730.2 → XP_038961658.1 BPI fold-containing family A member 2 isoform X1

Conserved Domains (1) summary

pfam01273
Location:77 → 246

LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain