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    F13b coagulation factor XIII B chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F13bprovided by RGD
    Official Full Name
    coagulation factor XIII B chainprovided by RGD
    Primary source
    RGD:1311668
    See related
    EnsemblRapid:ENSRNOG00000012613 AllianceGenome:RGD:1311668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in blood coagulation, fibrin clot formation. Orthologous to human F13B (coagulation factor XIII B chain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1190.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See F13b in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (53681639..53707114)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (51130908..51156383)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (56598891..56623132)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 41 Neighboring gene assembly factor for spindle microtubules Neighboring gene U4 spliceosomal RNA Neighboring gene complement factor H-related 2 Neighboring gene complement factor H-related 2-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations affecting disulphide bonds contribute to a fairly common prevalence of F13B gene defects: results of a genetic study in 14 families with factor XIII B deficiency. Ivaskevicius V, et al. Haemophilia, 2010 Jul 1. PMID 20331752
    2. Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Souri M, et al. Int J Hematol, 2008 Jan. PMID 18224415
    3. Fibrinogen and fibrin structure and functions. Mosesson MW. J Thromb Haemost, 2005 Aug. PMID 16102057
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor XIII B chain
    Names
    coagulation factor XIII, B polypeptide
    coagulation factor XIII, beta subunit
    NP_001388239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401310.1 → NP_001388239.1  coagulation factor XIII B chain precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2KAS2, A6ICM7, B1H260, F6Q1N1
      Related
      ENSRNOP00000016944.8, ENSRNOT00000016944.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      53681639..53707114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105956.1: Suppressed sequence

      Description
      NM_001105956.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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