Gars1 glycyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gars1provided by RGD
Official Full Name: glycyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1307856
See related: EnsemblRapid:ENSRNOG00000011052 AllianceGenome:RGD:1307856
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GlyRS; RGD1559871
Summary: Predicted to enable several functions, including bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; and identical protein binding activity. Predicted to be involved in diadenosine tetraphosphate biosynthetic process and mitochondrial glycyl-tRNA aminoacylation. Predicted to act upstream of or within glycyl-tRNA aminoacylation. Predicted to be located in several cellular components, including axon; extracellular exosome; and secretory granule. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 202.2), Kidney (RPKM 199.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85484939..85542876)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84171596..84212609)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85235122..85276085)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142694 (e-PCR)
- UniSTS:231941

RH133826 (e-PCR)
- UniSTS:217109

D7S2049E (e-PCR)
- UniSTS:151112

BM384835 (e-PCR)
- UniSTS:261209

Gars (e-PCR), detects polymorphism
- UniSTS:546786

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP:ATP adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISO Inferred from Sequence Orthology more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables glycine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables glycine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diadenosine tetraphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in diadenosine tetraphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in diadenosine tetraphosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial glycyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA aminoacylation for protein translation	ISO Inferred from Sequence Orthology more info
involved_in tRNA aminoacylation for protein translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycine--tRNA ligase

Names: AP-4-A synthetase; ap4A synthetase; diadenosine tetraphosphate synthetase

NP_001258068.1

EC 6.1.1.14

XP_063141841.1

EC 6.1.1.14

XP_063141842.1

EC 6.1.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.