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    Emc7 ER membrane protein complex subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Emc7provided by RGD
    Official Full Name
    ER membrane protein complex subunit 7provided by RGD
    Primary source
    RGD:1305045
    See related
    EnsemblRapid:ENSRNOG00000005884 AllianceGenome:RGD:1305045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305045
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC7 (ER membrane protein complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 489.0), Kidney (RPKM 428.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Emc7 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (119714617..119728748)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (99263933..99274365)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (103945276..103955970)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 6 Neighboring gene 60S ribosomal protein L19-like Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene small nucleolar RNA SNORA11 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene apoptosis and caspase activation inhibitor Neighboring gene proteasome subunit beta type-3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining human ERAD networks through an integrative mapping strategy. Christianson JC, et al. Nat Cell Biol, 2011 Nov 27. PMID 22119785, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 7
    Names
    UPF0480 protein C15orf24 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399270.1 → NP_001386199.1  ER membrane protein complex subunit 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HP51, D3ZQL1
      Related
      ENSRNOP00000008364.6, ENSRNOT00000008364.9
      Conserved Domains (1) summary
      pfam09430
      Location:56 → 167
      DUF2012; Protein of unknown function (DUF2012)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      119714617..119728748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591570.3 → XP_017447059.1  ER membrane protein complex subunit 7 isoform X1

      Conserved Domains (1) summary
      pfam09430
      Location:19 → 107
      DUF2012; Protein of unknown function (DUF2012)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106496.1: Suppressed sequence

      Description
      NM_001106496.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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