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    ABCC4 multidrug resistance-associated protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819392, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCC4
    Official Full Name
    multidrug resistance-associated protein 4
    Primary source
    TAIR:AT2G47800
    Locus tag
    AT2G47800
    See related
    Araport:AT2G47800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMRP4; ATP-binding cassette C4; EST3; F17A22.19; MRP4; multidrug resistance-associated protein 4
    Summary
    Encodes a plasma membrane localized ATPase transporter involved in multidrug transport. The expression of this gene is upregulated by herbicide safeners such as benoxacor, fluxofenim and fenclorim.
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    Genomic context

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    See ABCC4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (19574666..19580615)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Rubber elongation factor protein (REF) Neighboring gene TSPO(outer membrane tryptophan-rich sensory protein)-like protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene nuclear factor Y, subunit B5 Neighboring gene arginine-glutamic acid dipeptide repeat protein Neighboring gene Cation efflux family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of AtMRP4, a guard cell plasma membrane ABCC-type ABC transporter, leads to deregulation of stomatal opening and increased drought susceptibility. Klein M, et al. Plant J, 2004 Jul. PMID 15225287
    2. Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line. Pérez-Pineda SI, et al. Ann Hepatol, 2021 Sep-Oct. PMID 33582321
    3. Organization and function of the plant pleiotropic drug resistance ABC transporter family. Crouzet J, et al. FEBS Lett, 2006 Feb 13. PMID 16506311
    4. Mechanical stress induces biotic and abiotic stress responses via a novel cis-element. Walley JW, et al. PLoS Genet, 2007 Oct. PMID 17953483, Free PMC Article
    5. Nematode-induced changes of transporter gene expression in Arabidopsis roots. Hammes UZ, et al. Mol Plant Microbe Interact, 2005 Dec. PMID 16478044

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
      Title: Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130347.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables folic acid transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to nematode HEP PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in vacuolar membrane HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    multidrug resistance-associated protein 4
    NP_182301.1
    • multidrug resistance-associated protein 4 (MRP4); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, folic acid transporter activity; INVOLVED IN: response to water deprivation, drug transmembrane transport, response to wounding, response to nematode, stomatal movement; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 10 (TAIR:AT3G62700.1); Has 714857 Blast hits to 368077 proteins in 3991 species: Archae - 12925; Bacteria - 579268; Metazoa - 12980; Fungi - 8565; Plants - 6599; Viruses - 19; Other Eukaryotes - 94501 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19574666..19580615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130347.5 → NP_182301.1  multidrug resistance-associated protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24525, Q0WVT4, Q7DM58
      UniProtKB/TrEMBL
      A0A7G2EET4
      Conserved Domains (4) summary
      cd03244
      Location:1272 → 1492
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:641 → 841
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:255 → 1502
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:976 → 1229
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7DM58.2

    Gene LinkOut

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