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    NAT12 nucleobase-ascorbate transporter 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817328, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAT12
    Official Full Name
    nucleobase-ascorbate transporter 12
    Primary source
    TAIR:AT2G27810
    Locus tag
    AT2G27810
    See related
    Araport:AT2G27810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS NUCLEOBASE-ASCORBATE TRANSPORTER 12; ATNAT12; F15K20.9; F15K20_9; nucleobase-ascorbate transporter 12
    Summary
    Encodes a plasma-membrane localized nucleobase transporter capable of transporting adenine, guanine, uracil and hypoxanthine. Likely to be a proton-nucleobase symporter.
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    Genomic context

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    See NAT12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (11852078..11856335)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene prephenate dehydratase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical characterization and structure-function relationship of two plant NCS2 proteins, the nucleobase transporters NAT3 and NAT12 from Arabidopsis thaliana. Niopek-Witz S, et al. Biochim Biophys Acta, 2014 Dec. PMID 25135661
    2. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001084501.1
    NM_001336128.1
    NM_179777.2
    NM_201821.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:monoatomic cation symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uracil transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within guanine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hypoxanthine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within uracil import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleobase-ascorbate transporter 12
    NP_001077970.1
    • nucleobase-ascorbate transporter 12; FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT4G38050.1); Has 8924 Blast hits to 8893 proteins in 1864 species: Archae - 69; Bacteria - 7265; Metazoa - 476; Fungi - 122; Plants - 377; Viruses - 11; Other Eukaryotes - 604 (source: NCBI BLink).
    NP_850108.1
    • nucleobase-ascorbate transporter 12 (NAT12); FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT4G38050.1); Has 9528 Blast hits to 9485 proteins in 1925 species: Archae - 69; Bacteria - 7579; Metazoa - 494; Fungi - 167; Plants - 469; Viruses - 16; Other Eukaryotes - 734 (source: NCBI BLink).
    NP_973550.2
    • nucleobase-ascorbate transporter 12; FUNCTIONS IN: transmembrane transporter activity; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Xanthine/uracil/vitamin C permease (InterPro:IPR006043); BEST Arabidopsis thaliana protein match is: Xanthine/uracil permease family protein (TAIR:AT4G38050.1); Has 9357 Blast hits to 9320 proteins in 1916 species: Archae - 69; Bacteria - 7552; Metazoa - 479; Fungi - 160; Plants - 390; Viruses - 14; Other Eukaryotes - 693 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11852078..11856335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179777.2 → NP_850108.1  nucleobase-ascorbate transporter 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850108.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E7D0, Q8LPL9, Q9ZUY2
      UniProtKB/TrEMBL
      A0A654EWS6
      Conserved Domains (2) summary
      pfam00860
      Location:184 → 602
      Xan_ur_permease; Permease family
      cl23746
      Location:186 → 604
      HCO3_cotransp; HCO3- transporter family

    2. NM_001336128.1 → NP_001323574.1  nucleobase-ascorbate transporter 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VT77, A0A1P8AXK2

    3. NM_201821.2 → NP_973550.2  nucleobase-ascorbate transporter 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973550.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X2B0, A0A654EWS6
      Conserved Domains (2) summary
      pfam00860
      Location:184 → 589
      Xan_ur_permease; Permease family
      cl23746
      Location:186 → 589
      HCO3_cotransp; HCO3- transporter family

    4. NM_001084501.1 → NP_001077970.1  nucleobase-ascorbate transporter 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MS07
      Conserved Domains (1) summary
      cl23746
      Location:186 → 542
      HCO3_cotransp; HCO3- transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E7D0.3

    Gene LinkOut

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