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    Eukaryotic translation initiation factor 2 subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818621, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Eukaryotic translation initiation factor 2 subunit 1
    Primary source
    TAIR:AT2G40290
    Locus tag
    AT2G40290
    See related
    Araport:AT2G40290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T7M7.14
    Summary
    Encodes an eIF2alpha homolog that can be phosphorylated by GCN2 in vitro.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (16828766..16831226, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Protein kinase family protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ferritin 4 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene autophagy-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates. Li MW, et al. Plant Biol (Stuttg), 2013 Jan. PMID 22672016
    2. Analysis of the Arabidopsis nuclear proteome and its response to cold stress. Bae MS, et al. Plant J, 2003 Dec. PMID 14617066
    3. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
    4. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
      Title: The GCN2 homologue in Arabidopsis thaliana interacts with uncharged tRNA and uses Arabidopsis eIF2α molecules as direct substrates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036441.1
    NM_129587.3
    NM_201919.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 2 subunit 1
    NP_001031518.1
    • Eukaryotic translation initiation factor 2 subunit 1; FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 alpha subunit (TAIR:AT5G05470.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_565927.1
    • Eukaryotic translation initiation factor 2 subunit 1; FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 alpha subunit (TAIR:AT5G05470.1); Has 4919 Blast hits to 4230 proteins in 1696 species: Archae - 235; Bacteria - 3462; Metazoa - 170; Fungi - 142; Plants - 94; Viruses - 32; Other Eukaryotes - 784 (source: NCBI BLink).
    NP_973648.1
    • Eukaryotic translation initiation factor 2 subunit 1; FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: translation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Ribosomal protein S1, RNA-binding domain (InterPro:IPR003029), Eukaryotic translation initiation factor 2, alpha subunit (InterPro:IPR011488); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 2 alpha subunit (TAIR:AT5G05470.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16828766..16831226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129587.3 → NP_565927.1  Eukaryotic translation initiation factor 2 subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565927.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LEV8, Q9SIZ2
      UniProtKB/TrEMBL
      A0A178VYF4, A0A5S9X5P1, Q9XEF6
      Conserved Domains (1) summary
      PTZ00248
      Location:4 → 315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional

    2. NM_201919.1 → NP_973648.1  Eukaryotic translation initiation factor 2 subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVK1
      Conserved Domains (2) summary
      cd04452
      Location:18 → 93
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      pfam07541
      Location:131 → 225
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

    3. NM_001036441.1 → NP_001031518.1  Eukaryotic translation initiation factor 2 subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031518.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVK1
      Conserved Domains (2) summary
      cd04452
      Location:18 → 93
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      pfam07541
      Location:131 → 225
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIZ2.2

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