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    TIF3H1 translation initiation factor 3 subunit H1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837627, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIF3H1
    Official Full Name
    translation initiation factor 3 subunit H1
    Primary source
    TAIR:AT1G10840
    Locus tag
    AT1G10840
    See related
    Araport:AT1G10840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T16B5.2; T16B5_2; translation initiation factor 3 subunit H1
    Summary
    Encodes eukaryotic initiation factor 3H1 subunit (TIF3H1).
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    Genomic context

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    See TIF3H1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (3607631..3610616, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF3755) Neighboring gene 15-cis-zeta-carotene isomerase Neighboring gene ncRNA Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene cytochrome C oxidase assembly factor Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation. Kim BH, et al. Genome Biol, 2007. PMID 17439654, Free PMC Article
    2. The global translation profile in a ribosomal protein mutant resembles that of an eIF3 mutant. Tiruneh BS, et al. BMC Biol, 2013 Dec 30. PMID 24377433, Free PMC Article
    3. The Arabidopsis eukaryotic translation initiation factor 3, subunit F (AteIF3f), is required for pollen germination and embryogenesis. Xia C, et al. Plant J, 2010 Jul. PMID 20444226, Free PMC Article
    4. TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h. Schepetilnikov M, et al. EMBO J, 2013 Apr 17. PMID 23524850, Free PMC Article
    5. Translational regulation via 5' mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Kim TH, et al. Plant Cell, 2004 Dec. PMID 15548739, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data represent the first genome-wide analysis of translation in a eukaryote defective in the large ribosomal subunit. RPL24 and eIF3h play similar but non-identical roles in eukaryotic translation.
      Title: The global translation profile in a ribosomal protein mutant resembles that of an eIF3 mutant.
    2. Authors propose that TOR functions in polysomes to maintain the active S6K1 (and thus eIF3h) phosphorylation status that is critical for translation reinitiation.
      Title: TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h.
    3. The intact eIF3h protein contributes to efficient translation initiation on 5' leader sequences harboring multiple uORFs.
      Title: On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_100960.3
    NM_202079.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to maltose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor 3 subunit H1
    NP_563880.1
    • translation initiation factor 3 subunit H1 (TIF3H1); CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555); Has 1300 Blast hits to 1299 proteins in 247 species: Archae - 0; Bacteria - 0; Metazoa - 532; Fungi - 366; Plants - 231; Viruses - 0; Other Eukaryotes - 171 (source: NCBI BLink).
    NP_973808.1
    • translation initiation factor 3 subunit H1 (TIF3H1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3607631..3610616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100960.3 → NP_563880.1  translation initiation factor 3 subunit H1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I5Y8, Q9C5Z2, Q9SAB9
      UniProtKB/TrEMBL
      A0A178WN13, A0A5S9TQ65, A0A7G2DVV7
      Conserved Domains (1) summary
      cd08065
      Location:23 → 286
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h

    2. NM_202079.1 → NP_973808.1  translation initiation factor 3 subunit H1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5Z2
      Conserved Domains (1) summary
      cd08065
      Location:1 → 199
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5Z2.2

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