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    UGT74F2 UDP-glucosyltransferase 74F2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818986, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UGT74F2
    Official Full Name
    UDP-glucosyltransferase 74F2
    Primary source
    TAIR:AT2G43820
    Locus tag
    AT2G43820
    See related
    Araport:AT2G43820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana salicylic acid glucosyltransferase 1; ATSAGT1; F18O19.7; GT; SAGT1; salicylic acid glucosyltransferase 1; SGT1; UDP-glucose:salicylic acid glucosyltransferase 1; UDP-glucosyltransferase 74F2
    Summary
    Induced by Salicylic acid, virus, fungus and bacteria.Involved in the tryptophan synthesis pathway. Independent of NPR1 for their induction by salicylic acid. UGT74F1 transfers UDP:glucose to salicylic acid (forming a glucoside (SAG) and a glucose ester (SGE)), benzoic acid, and athranilate in vitro. UGT74F2 shows a weak ability to catalyze the formation of the p-aminobenzoate-glucose ester in vitro. But, UGT75B1 appears to be the dominant pABA acylglucosyltransferase in vivo based on assays in leaves, flowers, and siliques. The true biological substrate(s) of UGT74F2 are not known, but mutant plants lacking UGT74F2 have a decreased level of SAG and SGE.
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    Genomic context

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    See UGT74F2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (18152078..18153908)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Actin-binding FH2 (formin homology 2) family protein Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene miscRNA Neighboring gene UDP-glycosyltransferase 74 F1 Neighboring gene ncRNA Neighboring gene Integrin-linked protein kinase family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of AtSGT1, an Arabidopsis salicylic acid glucosyltransferase, leads to increased susceptibility to Pseudomonas syringae. Song JT, et al. Phytochemistry, 2008 Mar. PMID 18226820
    2. Induction of a salicylic acid glucosyltransferase, AtSGT1, is an early disease response in Arabidopsis thaliana. Song JT. Mol Cells, 2006 Oct 31. PMID 17085977
    3. Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana. George Thompson AM, et al. Sci Rep, 2017 Apr 20. PMID 28425481, Free PMC Article
    4. The expression patterns of AtBSMT1 and AtSAGT1 encoding a salicylic acid (SA) methyltransferase and a SA glucosyltransferase, respectively, in Arabidopsis plants with altered defense responses. Song JT, et al. Mol Cells, 2009 Aug 31. PMID 19669626
    5. Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2 glucosyltransferase mutants of Arabidopsis thaliana. Dean JV, et al. Physiol Plant, 2008 Apr. PMID 18248508

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salicylic acid (SA) glucose conjugates are formed by two homologous UDP-glucosyltransferases (UGT74F1 and UGT74F2) that transfer glucose from UDP-glucose to SA.
      Title: Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana.
    2. Data show that the AtSAGT1-RNAi line exhibited no altered phenotypes upon pathogen infection, suggesting that (an)other SA glucosyltransferase(s) in Arabidopsis plants may be important for the pathogenesis of P. syringae. [AtSAGT1]
      Title: The expression patterns of AtBSMT1 and AtSAGT1 encoding a salicylic acid (SA) methyltransferase and a SA glucosyltransferase, respectively, in Arabidopsis plants with altered defense responses.
    3. The reduced resistance by AtSGT1 overexpression results from a reduction in salicylic acid content, which is at least in part caused by increases in methyl salicylate 2-O-beta-D-glucoside and methyl salicylate levels at the expense of salicylic acid.
      Title: Overexpression of AtSGT1, an Arabidopsis salicylic acid glucosyltransferase, leads to increased susceptibility to Pseudomonas syringae.
    4. isolation & characterization of UDP-glucose:salicylic acid glucosyltransferase1 (AtSGT1) gene; AtSGT1 was rapidly induced by exogenous SA & infection with Pseudomonas syringae, indicating pathogen-inducible AtSGT1 expression is an early disease response
      Title: Induction of a salicylic acid glucosyltransferase, AtSGT1, is an early disease response in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_129944.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-glucose:4-aminobenzoate acylglucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables benzoic acid glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nicotinate-O-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid glucosyltransferase (ester-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid glucosyltransferase (glucoside-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within benzoate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within para-aminobenzoic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within salicylic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucosyltransferase 74F2
    NP_181910.1
    • UDP-glucosyltransferase 74F2 (UGT74F2); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glycosyltransferase 74 F1 (TAIR:AT2G43840.1); Has 8409 Blast hits to 8329 proteins in 546 species: Archae - 0; Bacteria - 818; Metazoa - 2323; Fungi - 31; Plants - 5038; Viruses - 125; Other Eukaryotes - 74 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18152078..18153908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129944.3 → NP_181910.1  UDP-glucosyltransferase 74F2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181910.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22822
      UniProtKB/TrEMBL
      A0A178VQS4, A0A384KK07, A0A5S9X6R2, W8Q3A1
      Conserved Domains (1) summary
      PLN02173
      Location:1 → 449
      PLN02173; UDP-glucosyl transferase family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22822.1

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