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    DML2 demeter-like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820162, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DML2
    Official Full Name
    demeter-like 2
    Primary source
    TAIR:AT3G10010
    Locus tag
    AT3G10010
    See related
    Araport:AT3G10010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    demeter-like 2
    Summary
    Encodes a protein with DNA glycosylase activity that is involved in maintaining methylation marks.
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    Genomic context

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    See DML2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    21
    Sequence:
    Chromosome: 3; NC_003074.8 (3081735..3088550, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Nucleoside transporter family protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene tRNA-Leu Neighboring gene plant/protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks. Ortega-Galisteo AP, et al. Plant Mol Biol, 2008 Aug. PMID 18493721
    2. DNA demethylases target promoter transposable elements to positively regulate stress responsive genes in Arabidopsis. Le TN, et al. Genome Biol, 2014 Sep 17. PMID 25228471, Free PMC Article
    3. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROS1, DML2, and DML3 play a role in fungal disease resistance in Arabidopsis
      Title: DNA demethylases target promoter transposable elements to positively regulate stress responsive genes in Arabidopsis.
    2. Results suggest that DML2 is required not only for removing DNA methylation marks from improperly-methylated cytosines, but also for maintenance of high methylation levels in properly targeted sites.
      Title: Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111836.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    demeter-like 2
    NP_187612.5
    • demeter-like 2 (DML2); FUNCTIONS IN: 4 iron, 4 sulfur cluster binding, catalytic activity, endonuclease activity; INVOLVED IN: DNA repair, base-excision repair; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: demeter-like 1 (TAIR:AT2G36490.1); Has 3292 Blast hits to 3211 proteins in 1332 species: Archae - 246; Bacteria - 2331; Metazoa - 80; Fungi - 82; Plants - 273; Viruses - 0; Other Eukaryotes - 280 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3081735..3088550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337853.1 → NP_001326647.1  demeter-like 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J2I4, Q9SR66
      UniProtKB/TrEMBL
      A0A5S9XAX4

    2. NM_111836.5 → NP_187612.5  demeter-like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187612.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J2I4, Q9SR66
      UniProtKB/TrEMBL
      A0A5S9XAX4
      Conserved Domains (4) summary
      smart00525
      Location:969 → 989
      FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
      smart00478
      Location:819 → 967
      ENDO3c; endonuclease III
      pfam15628
      Location:1219 → 1320
      RRM_DME; RRM in Demeter
      pfam15629
      Location:1184 → 1216
      Perm-CXXC; Permuted single zf-CXXC unit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SR66.2

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