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    ADSS adenylosuccinate synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADSS
    Official Full Name
    adenylosuccinate synthase
    Primary source
    TAIR:AT3G57610
    Locus tag
    AT3G57610
    See related
    Araport:AT3G57610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adenylosuccinate synthase; ATPURA
    Summary
    encoding adenylosuccinate synthetase (AdSS), the enzyme involved in the first step of the formation of the purine nucleotide AMP (conversion of IMP to adenylo-succinate)
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    Genomic context

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    See ADSS in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (21334191..21336720, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene glyoxal oxidase-related protein Neighboring gene exostosin family protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase. Fonné-Pfister R, et al. Proc Natl Acad Sci U S A, 1996 Sep 3. PMID 8790347, Free PMC Article
    2. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115621.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenylosuccinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylosuccinate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within AMP biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    adenylosuccinate synthase
    NP_191320.1
    • adenylosuccinate synthase (ADSS); FUNCTIONS IN: adenylosuccinate synthase activity; INVOLVED IN: response to cadmium ion, purine ribonucleotide biosynthetic process, AMP biosynthetic process; LOCATED IN: apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Adenylosuccinate synthase, active site (InterPro:IPR018220), Adenylosuccinate synthetase (InterPro:IPR001114); Has 10496 Blast hits to 10490 proteins in 2781 species: Archae - 222; Bacteria - 5613; Metazoa - 213; Fungi - 143; Plants - 71; Viruses - 18; Other Eukaryotes - 4216 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21334191..21336720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115621.5 → NP_191320.1  adenylosuccinate synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96529
      UniProtKB/TrEMBL
      A0A5S9XNF3, A0A654FIP2, Q8LEZ6
      Conserved Domains (1) summary
      PLN02513
      Location:65 → 490
      PLN02513; adenylosuccinate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96529.1

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