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    Galactose oxidase/kelch repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825164, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Galactose oxidase/kelch repeat superfamily protein
    Primary source
    TAIR:AT3G59940
    Locus tag
    AT3G59940
    See related
    Araport:AT3G59940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Kelch repeat F-box 50; KFB50; KISS ME DEADLY 4; KMD4
    Summary
    Encodes a member of a family of F-box proteins, called the KISS ME DEADLY (KMD) family, that targets type-B ARR proteins for degradation and is involved in the negative regulation of the cytokinin response. Also named as KFB50, a member of a group of Kelch repeat F-box proteins that negatively regulate phenylpropanoid biosynthesis by targeting the phenypropanoid biosynthesis enzyme phenylalanine ammonia-lyase.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (22142856..22144439)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene defensin-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Peptidase family C54 protein Neighboring gene ncRNA Neighboring gene histone-lysine N-methyltransferase ASHH4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Kelch repeat F-box proteins regulate phenylpropanoid biosynthesis via controlling the turnover of phenylalanine ammonia-lyase. Zhang X, et al. Plant Cell, 2013 Dec. PMID 24363316, Free PMC Article
    2. SCF(KMD) controls cytokinin signaling by regulating the degradation of type-B response regulators. Kim HJ, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23720308, Free PMC Article
    3. ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance. Campe R, et al. New Phytol, 2016 Jan. PMID 26315018
    4. Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis. Risseeuw EP, et al. Plant J, 2003 Jun. PMID 12795696
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115857.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cytokinin-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of phenylpropanoid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Galactose oxidase/kelch repeat superfamily protein
    NP_191553.1
    • Galactose oxidase/kelch repeat superfamily protein; CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 1 (InterPro:IPR006652), Kelch related (InterPro:IPR013089), Kelch-type beta propeller (InterPro:IPR015915); BEST Arabidopsis thaliana protein match is: Galactose oxidase/kelch repeat superfamily protein (TAIR:AT2G44130.1); Has 2977 Blast hits to 2510 proteins in 188 species: Archae - 4; Bacteria - 251; Metazoa - 1720; Fungi - 24; Plants - 858; Viruses - 0; Other Eukaryotes - 120 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22142856..22144439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115857.2 → NP_191553.1  Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191553.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L991, Q9M1Y1
      UniProtKB/TrEMBL
      A0A178VAS9, A0A5S9XN35, A0A654FJD4
      Conserved Domains (4) summary
      smart00256
      Location:19 → 59
      FBOX; A Receptor for Ubiquitination Targets
      PHA03098
      Location:121 → 296
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:196 → 242
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:195 → 242
      Kelch_1; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1Y1.1

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