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    AtATG18a Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825452, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AtATG18a
    Official Full Name
    Transducin/WD40 repeat-like superfamily protein
    Primary source
    TAIR:AT3G62770
    Locus tag
    AT3G62770
    See related
    Araport:AT3G62770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATG18a; autophagy 18a; PEROXISOME UNUSUAL POSITIONING 2; PEUP2
    Summary
    Required for autophagosome formation during nutrient deprivation and senescence.
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    Genomic context

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    See AtATG18a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (23218610..23221243, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene beta glucosidase 8 Neighboring gene Glutathione S-transferase family protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene NADH-ubiquinone oxidoreductase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis Rab18 GTPase promotes autophagy by tethering ATG18a to the ER in response to nutrient starvation. Sun J, et al. Dev Cell, 2023 Dec 18. PMID 38056450
    2. Persulfidation of ATG18a regulates autophagy under ER stress in Arabidopsis. Aroca A, et al. Proc Natl Acad Sci U S A, 2021 May 18. PMID 33975948, Free PMC Article
    3. A possible involvement of autophagy in amyloplast degradation in columella cells during hydrotropic response of Arabidopsis roots. Nakayama M, et al. Planta, 2012 Oct. PMID 22532286
    4. The autophagy gene, ATG18a, plays a negative role in powdery mildew resistance and mildew-induced cell death in Arabidopsis. Wang Y, et al. Plant Signal Behav, 2011 Sep. PMID 21847024, Free PMC Article
    5. Autophagy is required for tolerance of drought and salt stress in plants. Liu Y, et al. Autophagy, 2009 Oct. PMID 19587533

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Arabidopsis Rab18 GTPase promotes autophagy by tethering ATG18a to the ER in response to nutrient starvation.
      Title: An Arabidopsis Rab18 GTPase promotes autophagy by tethering ATG18a to the ER in response to nutrient starvation.
    2. Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure.
      Title: Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure.
    3. Persulfidation of ATG18a regulates autophagy under ER stress in Arabidopsis.
      Title: Persulfidation of ATG18a regulates autophagy under ER stress in Arabidopsis.
    4. Data show that atg18a-2 is also resistant to the powdery mildew pathogen, Golovinomyces cichoracearum, and it shows mildew-induced cell death similar to the atg2 mutant.
      Title: The autophagy gene, ATG18a, plays a negative role in powdery mildew resistance and mildew-induced cell death in Arabidopsis.
    5. Data demonstrate the induction of autophagy in high salt and osmotic stress conditions, concomitant with the upregulation of expression of an Arabidopsis thaliana autophagy-related gene AtATG18a
      Title: Autophagy is required for tolerance of drought and salt stress in plants.
    6. AtATG18a protein is likely to be required for autophagosome formation during nutrient stress and senescence in Arabidopsis. [AtATG18a]
      Title: AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035841.4
    NM_116142.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Transducin/WD40 repeat-like superfamily protein
    NP_001030918.4
    • AtATG18a; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: autophagy, leaf senescence, response to starvation; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: homolog of yeast autophagy 18 (ATG18) D (TAIR:AT3G56440.1); Has 213 Blast hits to 211 proteins in 57 species: Archae - 0; Bacteria - 30; Metazoa - 48; Fungi - 45; Plants - 63; Viruses - 2; Other Eukaryotes - 25 (source: NCBI BLink).
    NP_567132.4
    • AtATG18a; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: autophagy, leaf senescence, response to starvation; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat (InterPro:IPR001680), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: homolog of yeast autophagy 18 (ATG18) D (TAIR:AT3G56440.1); Has 1516 Blast hits to 1443 proteins in 266 species: Archae - 0; Bacteria - 93; Metazoa - 578; Fungi - 450; Plants - 210; Viruses - 2; Other Eukaryotes - 183 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23218610..23221243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116142.6 → NP_567132.4  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567132.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EAF7, Q93VB2, Q9LZI8
      UniProtKB/TrEMBL
      A0A178V9Z7, A0A5S9XP05, A0A654FK75
      Conserved Domains (2) summary
      sd00039
      Location:169 → 204
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:134 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001035841.4 → NP_001030918.4  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030918.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FK75, F4IZI7
      Conserved Domains (3) summary
      COG2319
      Location:134 → 334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:169 → 204
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:134 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93VB2.1

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