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    HUA2 Tudor/PWWP/MBT domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832379, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HUA2
    Official Full Name
    Tudor/PWWP/MBT domain-containing protein
    Primary source
    TAIR:AT5G23150
    Locus tag
    AT5G23150
    See related
    Araport:AT5G23150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ENHANCER OF AG-4 2; MYJ24.14; MYJ24_14
    Summary
    Putative transcription factor. Member of the floral homeotic AGAMOUS pathway.Mutations in HUA enhance the phenotype of mild ag-4 allele. Single hua mutants are early flowering and have reduced levels of FLC mRNA. Other MADS box flowering time genes such as FLM and MAF2 also appear to be regulated by HUA2. HUA2 normally activates FLC expression and enhances AG function. HUA and HUA-LIKE (HULK) genes act redundantly to regulate a subset of essential genes, with some (or all) family members also having specific functions.
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    Genomic context

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    See HUA2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (7785743..7792991)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Peptidoglycan-binding LysM domain-containing protein Neighboring gene nuclear-encoded CLP protease P7 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation for anthocyanin accumulation under high-light and low-temperature stress is attributable to the ENHANCER OF AG-4 2 (HUA2) locus in combination with PRODUCTION OF ANTHOCYANIN PIGMENT1 (PAP1) and PAP2. Ilk N, et al. New Phytol, 2015 Apr. PMID 25425527
    2. HUA2 caused natural variation in shoot morphology of A. thaliana. Wang Q, et al. Curr Biol, 2007 Sep 4. PMID 17764945
    3. The synergistic activation of FLOWERING LOCUS C by FRIGIDA and a new flowering gene AERIAL ROSETTE 1 underlies a novel morphology in Arabidopsis. Poduska B, et al. Genetics, 2003 Apr. PMID 12702689, Free PMC Article
    4. AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana. Lemus T, et al. Genetics, 2023 Feb 9. PMID 36303325, Free PMC Article
    5. HUA1 and HUA2 are two members of the floral homeotic AGAMOUS pathway. Chen X, et al. Mol Cell, 1999 Mar. PMID 10198637

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana.
      Title: AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana.
    2. suggest that the HULK genes encode conserved nuclear factors with partially redundant but essential functions associated with diverse genetic pathways in plants
      Title: A plant-specific HUA2-LIKE (HULK) gene family in Arabidopsis thaliana is essential for development.
    3. Natural variation in HUA2 activity coordinates changes in two important life-history traits, flowering time and shoot morphology.
      Title: HUA2 caused natural variation in shoot morphology of A. thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122221.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anthocyanin accumulation in tissues in response to UV light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within maintenance of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Tudor/PWWP/MBT domain-containing protein
    NP_197706.1
    • ENHANCER OF AG-4 2 (HUA2); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF618 (InterPro:IPR006903), RNA polymerase II, large subunit, CTD (InterPro:IPR006569), PWWP (InterPro:IPR000313); BEST Arabidopsis thaliana protein match is: Tudor/PWWP/MBT domain-containing protein (TAIR:AT5G08230.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7785743..7792991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343791.1 → NP_001330849.1  Tudor/PWWP/MBT domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UI48, A0A1P8BC24, A0A654G3M4

    2. NM_001343792.1 → NP_001330848.1  Tudor/PWWP/MBT domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XER9
      UniProtKB/TrEMBL
      A0A178UI48, A0A654G3M4

    3. NM_122221.3 → NP_197706.1  Tudor/PWWP/MBT domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197706.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XER9
      UniProtKB/TrEMBL
      A0A178UI48, A0A654G3M4
      Conserved Domains (2) summary
      cd05834
      Location:16 → 104
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      smart00582
      Location:778 → 909
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XER9.1

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