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    CYP705A5 cytochrome P450, family 705, subfamily A, polypeptide 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834850, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP705A5
    Official Full Name
    cytochrome P450, family 705, subfamily A, polypeptide 5
    Primary source
    TAIR:AT5G47990
    Locus tag
    AT5G47990
    See related
    Araport:AT5G47990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; family 705; MDN11.4; MDN11_4; polypeptide 5; subfamily A; THAD; THAD1; THALIAN-DIOL DESATURASE
    Summary
    Encodes an endomembrane system-expressed member of the CYP705A family of cytochrome P450 enzymes. It appears to catalyze the addition of a double bond to thalian-diol at carbon 15. Reduced levels of THAD expression lead to a build up of thalian-diol in root extracts. thad1-1 mutants also have longer roots than wild type seedlings and show altered gravitropic responses.
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    Genomic context

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    See CYP705A5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (19434758..19436749)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene ncRNA Neighboring gene cytochrome P450, family 708, subfamily A, polypeptide 2 Neighboring gene thalianol synthase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gravity Persistent Signal 1 (GPS1) reveals novel cytochrome P450s involved in gravitropism. Withers JC, et al. Am J Bot, 2013 Jan. PMID 23284057
    2. Metabolic diversification--independent assembly of operon-like gene clusters in different plants. Field B, et al. Science, 2008 Apr 25. PMID 18356490
    3. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Field B, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21876149, Free PMC Article
    4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124173.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thalian-diol desaturase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flavonol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thalianol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 705, subfamily A, polypeptide 5
    NP_199610.1
    • ''cytochrome P450, family 705, subfamily A, polypeptide 5'' (CYP705A5); FUNCTIONS IN: oxygen binding, thalian-diol desaturase activity; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 705, subfamily A, polypeptide 32 (TAIR:AT3G20950.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19434758..19436749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124173.3 → NP_199610.1  cytochrome P450, family 705, subfamily A, polypeptide 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FI39
      UniProtKB/TrEMBL
      A0A178UGC2, A0A654G992
      Conserved Domains (1) summary
      cd20655
      Location:75 → 504
      CYP93; cytochrome P450 family 93
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FI39.1

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