FCLY farnesylcysteine lyase [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: FCLY
Official Full Name: farnesylcysteine lyase
Primary source: TAIR:AT5G63910
Locus tag: AT5G63910
See related: Araport:AT5G63910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: farnesylcysteine lyase; MGI19.4; MGI19_4
Summary: Encodes a farnesylcysteine lyase (EC 1.8.3.5) involved in a salvage /detoxification pathway of farnesylcysteine (FC) residues that are liberated during the degradation of prenylated proteins. Because FC is a competitive inhibitor of prenylcysteine methyltransferases involved in the down-regulation of ABA signaling, fcly mutants with elevated FC levels are hypersensitive to ABA. The protein also appears to be glycosylated when translated in vitro in the presence of microsomal membranes and it likely requires FAD for enzymatic activity.
NEW: Try the new Gene table
Try the new Transcript table

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.(
Title: Farnesylcysteine lyase is involved in negative regulation of abscisic acid signaling in Arabidopsis.

Submit: New GeneRIF Correction

NM_125787.5

Function	Evidence Code	Pubs
enables farnesylcysteine lyase activity	IEA Inferred from Electronic Annotation more info
enables prenylcysteine oxidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within farnesyl diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prenylated protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prenylcysteine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plant-type vacuole	HDA more info	PubMed

NP_201196.1

farnesylcysteine lyase (FCLY); FUNCTIONS IN: prenylcysteine oxidase activity; INVOLVED IN: prenylated protein catabolic process, abscisic acid mediated signaling pathway, farnesyl diphosphate metabolic process; LOCATED IN: plasma membrane, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Prenylcysteine lyase (InterPro:IPR010795), Prenylcysteine oxidase (InterPro:IPR017046); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain