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    BARS1 baruol synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827203, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BARS1
    Official Full Name
    baruol synthase 1
    Primary source
    TAIR:AT4G15370
    Locus tag
    AT4G15370
    See related
    Araport:AT4G15370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    baruol synthase 1; DL3730C; FCAALL.279; PEN2; PENTACYCLIC TRITERPENE SYNTHASE 2
    Summary
    Encodes an oxidosqualene cyclase that primarily produces the tetracyclic triterpene baruol in vitro and when expressed in yeast. It can also make 22 other minor triterpenoid products with varying numbers of rings.
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    Genomic context

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    See BARS1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (8773730..8779685, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 2 Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 3 Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 4 Neighboring gene HXXXD-type acyl-transferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis. Lodeiro S, et al. J Am Chem Soc, 2007 Sep 12. PMID 17705488
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables baruol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within tetracyclic triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triterpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    baruol synthase 1
    NP_193272.1
    • baruol synthase 1 (BARS1); CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: pentacyclic triterpene synthase 1 (TAIR:AT4G15340.1); Has 1967 Blast hits to 1902 proteins in 561 species: Archae - 2; Bacteria - 837; Metazoa - 81; Fungi - 237; Plants - 604; Viruses - 0; Other Eukaryotes - 206 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8773730..8779685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117625.2 → NP_193272.1  baruol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193272.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23390
      UniProtKB/TrEMBL
      A0A654FPH7
      Conserved Domains (2) summary
      PLN03012
      Location:1 → 752
      PLN03012; Camelliol C synthase
      cd02892
      Location:99 → 752
      SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...

    2. NM_001341034.1 → NP_001329547.1  baruol synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B819, A0A654FPH7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23390.2

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