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    CLA1 Deoxyxylulose-5-phosphate synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827230, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLA1
    Official Full Name
    Deoxyxylulose-5-phosphate synthase
    Primary source
    TAIR:AT4G15560
    Locus tag
    AT4G15560
    See related
    Araport:AT4G15560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    1-deoxy-D-xylulose 5-phosphate (DXP) synthase 1; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE 2; AtCLA1; CLA; CLOROPLASTOS ALTERADOS 1; DEF; DL3821W; DXPS2; DXS; DXS1; FCAALL.24
    Summary
    Encodes a protein with 1-deoxyxylulose 5-phosphate synthase activity involved in the MEP pathway. It is essential for chloroplast development in Arabidopsis
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    Genomic context

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    See CLA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (8883825..8887667)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene EamA-like transporter family Neighboring gene PH-response transcription factor Neighboring gene indole-3-acetate beta-D-glucosyltransferase Neighboring gene superoxide dismutase 1 copper chaperone-like protein Neighboring gene F-box-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the expression of CLA1, a gene that encodes the 1-deoxyxylulose 5-phosphate synthase of the 2-C-methyl-D-erythritol-4-phosphate pathway in Arabidopsis. Estévez JM, et al. Plant Physiol, 2000 Sep. PMID 10982425, Free PMC Article
    2. Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis. Pulido P, et al. PLoS Genet, 2016 Jan. PMID 26815787, Free PMC Article
    3. Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism. Lange BM, et al. Plant Mol Biol, 2003 Apr. PMID 12777052
    4. Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control. Pulido P, et al. Plant Cell, 2013 Oct. PMID 24104567, Free PMC Article
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We conclude that specific J-proteins and Hsp100 chaperones act together with Hsp70 to recognize and deliver DXS to either reactivation (via ClpB3) or removal (via ClpC1) depending on the physiological status of the plastid.
      Title: Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_117647.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-deoxy-D-xylulose-5-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 1-deoxy-D-xylulose 5-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in terpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Deoxyxylulose-5-phosphate synthase
    NP_193291.1
    • CLOROPLASTOS ALTERADOS 1 (CLA1); FUNCTIONS IN: 1-deoxy-D-xylulose-5-phosphate synthase activity; INVOLVED IN: chlorophyll biosynthetic process, response to light stimulus, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transketolase, N-terminal (InterPro:IPR005474), Transketolase, C-terminal (InterPro:IPR005476), Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (InterPro:IPR009014), Transketolase-like, pyrimidine-binding domain (InterPro:IPR005475), Transketolase binding site (InterPro:IPR020826), Transketolase-like, C-terminal (InterPro:IPR015941), Deoxyxylulose-5-phosphate synthase (InterPro:IPR005477), Dehydrogenase, E1 component (InterPro:IPR001017); BEST Arabidopsis thaliana protein match is: 1-deoxy-D-xylulose 5-phosphate synthase 1 (TAIR:AT3G21500.2); Has 24450 Blast hits to 24392 proteins in 2940 species: Archae - 267; Bacteria - 15281; Metazoa - 526; Fungi - 278; Plants - 446; Viruses - 0; Other Eukaryotes - 7652 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8883825..8887667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117647.3 → NP_193291.1  Deoxyxylulose-5-phosphate synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23407, O49738, Q38854
      UniProtKB/TrEMBL
      A0A178V5I0, A0A5S9XSS6
      Conserved Domains (2) summary
      PLN02582
      Location:46 → 717
      PLN02582; 1-deoxy-D-xylulose-5-phosphate synthase
      cl03356
      Location:1 → 38
      DcrB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38854.2

    Gene LinkOut

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