Cd63 Cd63 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd63provided by RGD
Official Full Name: Cd63 moleculeprovided by RGD
Primary source: RGD:62080
See related: EnsemblRapid:ENSRNOG00000007650 AllianceGenome:RGD:62080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in several processes, including negative regulation of epithelial cell migration; positive regulation of cell adhesion; and positive regulation of endocytosis. Located in extracellular exosome. Part of protein-containing complex. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 2375.7), Heart (RPKM 1063.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1909538..1924937)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (1325108..1340447)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (3320250..3335583)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data provide a previously uncharacterized trophic action of TIMP-1 to regulate oligodendrocyte maturation via a CD63/beta1-integrin/Akt pathway mechanism.
Title: TIMP-1 Promotes Oligodendrocyte Differentiation Through Receptor-Mediated Signaling.
A disruption of cerebrospinal fluid exosomes in aged rats, evaluated by CD63 levels, can be related to susceptibility to neurodegenerative disorders.
Title: The Aging Process Alters IL-1β and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid.
These findings strongly suggest that CD63 and CD81 play an important role in Schwann cell spreading along axons but seem to be dispensable for Schwann cell myelination
Title: Tetraspanins are involved in Schwann cell-axon interaction.
ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1
Title: Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63.
CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity.
Title: Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
involved in extracellular matrix-basolateral membrane interactions
Title: Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137352 (e-PCR)
- UniSTS:219440

RH131837 (e-PCR)
- UniSTS:215120

RH125938 (e-PCR)
- UniSTS:162650

RH130054 (e-PCR)
- UniSTS:213342

RH139213 (e-PCR)
- UniSTS:221299

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome to melanosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to melanosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in pigment granule maturation	ISO Inferred from Sequence Orthology more info
involved_in pigment granule maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome lumen	IEA Inferred from Electronic Annotation more info
located_in endosome lumen	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in multivesicular body, internal vesicle	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CD63 antigen

Names: mast cell antigen AD1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017125.3 → NP_058821.1 CD63 antigen

See identical proteins and their annotated locations for NP_058821.1

Status: PROVISIONAL

Source sequence(s)

X61654

UniProtKB/Swiss-Prot

P28648

UniProtKB/TrEMBL

A0A8I5ZUS8, A6KSK3

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1909538..1924937

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263108.1 → XP_063119178.1 CD63 antigen isoform X1
XM_008765024.3 → XP_008763246.1 CD63 antigen isoform X3

UniProtKB/TrEMBL

A0A8I5ZUS8, A0A8I6GFY5

Conserved Domains (3) summary

cd03166
Location:129 → 227

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:33 → 255

Tetraspannin; Tetraspanin family

cl00413
Location:72 → 131

ATP-synt_A; ATP synthase A chain
XM_063263109.1 → XP_063119179.1 CD63 antigen isoform X2
XM_008765025.4 → XP_008763247.1 CD63 antigen isoform X4

See identical proteins and their annotated locations for XP_008763247.1

UniProtKB/Swiss-Prot

P28648

UniProtKB/TrEMBL

A0A8I5ZUS8, A6KSK3

Related

ENSRNOP00000082343.2, ENSRNOT00000095354.2

Conserved Domains (2) summary

cd03166
Location:105 → 203

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:10 → 227

Tetraspannin; Tetraspanin family