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    Igfals insulin-like growth factor binding protein, acid labile subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79438, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Igfalsprovided by RGD
    Official Full Name
    insulin-like growth factor binding protein, acid labile subunitprovided by RGD
    Primary source
    RGD:68429
    See related
    EnsemblRapid:ENSRNOG00000015061 AllianceGenome:RGD:68429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Als
    Summary
    Enables insulin-like growth factor binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; and cellular response to growth hormone stimulus. Part of insulin-like growth factor ternary complex. Orthologous to human IGFALS (insulin like growth factor binding protein acid labile subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 342.9) and Kidney (RPKM 47.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igfals in Genome Data Viewer
    Location:
    10q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14397076..14408439)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13897468..13903920)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14240308..14243554)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of the acid-labile subunit of rat serum insulin-like growth factor binding protein complex. Baxter RC, et al. Endocrinology, 1994 Feb. PMID 7507839
    2. Regulation of the acid-labile subunit of the insulin-like growth factor complex in cultured rat hepatocytes. Dai J, et al. Endocrinology, 1994 Sep. PMID 8070348
    3. Cloning and characterization of the rat gene for the acid-labile subunit of the insulin-like growth factor binding protein complex. Delhanty PJ, et al. J Mol Endocrinol, 1997 Dec. PMID 9460648
    4. Interleukin-1 beta suppresses growth hormone-induced acid-labile subunit mRNA levels and secretion in primary hepatocytes. Delhanty PJ. Biochem Biophys Res Commun, 1998 Feb 4. PMID 9473516
    5. Changes in the circulating IGF system during short-term fasting and refeeding in rats. Frystyk J, et al. Am J Physiol, 1999 Aug. PMID 10444419

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables insulin-like growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to growth hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of insulin-like growth factor ternary complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of insulin-like growth factor ternary complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of insulin-like growth factor ternary complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of insulin-like growth factor ternary complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein complex acid labile subunit
    Names
    insulin-like growth factor-binding protein complex acid labile chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053329.3 → NP_445781.3  insulin-like growth factor-binding protein complex acid labile subunit precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HCX9, F1LRE2, O70211
      Related
      ENSRNOP00000020233.5, ENSRNOT00000020233.7
      Conserved Domains (5) summary
      smart00013
      Location:40 → 78
      LRRNT; Leucine rich repeat N-terminal domain
      PLN00113
      Location:68 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:244 → 267
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:486 → 536
      LRR_8; Leucine rich repeat
      cl15307
      Location:535 → 578
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14397076..14408439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086922.2 → XP_038942850.1  insulin-like growth factor-binding protein complex acid labile subunit isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6E1, A6HCX8, O70211
      Conserved Domains (5) summary
      smart00013
      Location:40 → 78
      LRRNT; Leucine rich repeat N-terminal domain
      PLN00113
      Location:68 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:244 → 267
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:486 → 536
      LRR_8; Leucine rich repeat
      cl15307
      Location:535 → 578
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    2. XM_063269930.1 → XP_063126000.1  insulin-like growth factor-binding protein complex acid labile subunit isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35859.1 GenPept UniProtKB/Swiss-Prot:P35859

    Gene LinkOut

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