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    Cyc1 cytochrome c-1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300047, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyc1provided by RGD
    Official Full Name
    cytochrome c-1provided by RGD
    Primary source
    RGD:1306597
    See related
    EnsemblRapid:ENSRNOG00000012457 AllianceGenome:RGD:1306597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable electron transfer activity; heme binding activity; and metal ion binding activity. Involved in response to glucagon. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 2643.1), Muscle (RPKM 1732.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyc1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109947750..109950142)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108067106..108069483)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117409576..117411953)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene exosome component 4 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene SHANK-associated RH domain interactor Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of rats. Halestrap AP. Biochem J, 1978 Jun 15. PMID 210759, Free PMC Article
    2. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. Kuang E, et al. PLoS Genet, 2012. PMID 23093945, Free PMC Article
    3. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695
    4. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
    5. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to glucagon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277194.1 → NP_001264123.1  cytochrome c-1

      See identical proteins and their annotated locations for NP_001264123.1

      Status: VALIDATED

      Source sequence(s)
      FM122421, FN801980, JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HS83, D3ZFQ8
      Related
      ENSRNOP00000017067.8, ENSRNOT00000017067.9
      Conserved Domains (2) summary
      COG2857
      Location:85 → 288
      CYT1; Cytochrome c1 [Energy production and conversion]
      pfam02167
      Location:97 → 315
      Cytochrom_C1; Cytochrome C1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109947750..109950142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263310.1 → XP_063119380.1  cytochrome c-1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130491.1: Suppressed sequence

      Description
      NM_001130491.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials