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    Chrm4 cholinergic receptor, muscarinic 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25111, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chrm4provided by RGD
    Official Full Name
    cholinergic receptor, muscarinic 4provided by RGD
    Primary source
    RGD:2344
    See related
    EnsemblRapid:ENSRNOG00000017556 AllianceGenome:RGD:2344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    M4
    Summary
    Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Located in several cellular components, including asymmetric synapse; neuronal cell body; and sarcolemma. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.8) and Testes (RPKM 1.9) See more
    Orthologs
    NEW
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    Genomic context

    See Chrm4 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98349080..98356821)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77893425..77901166)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80833272..80841165)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene uncharacterized LOC134486121 Neighboring gene ATP synthase membrane subunit c locus 1, pseudogene 1 Neighboring gene diacylglycerol kinase zeta Neighboring gene midkine Neighboring gene cAMP responsive element binding protein 3-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M4
    Names
    cholinergic receptor, muscarin 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031547.1NP_113735.1  muscarinic acetylcholine receptor M4

      See identical proteins and their annotated locations for NP_113735.1

      Status: VALIDATED

      Source sequence(s)
      CR472483, DV213670, M16409
      UniProtKB/Swiss-Prot
      P08485
      UniProtKB/TrEMBL
      A6HNE6, G3V894
      Related
      ENSRNOP00000023586.4, ENSRNOT00000023583.7
      Conserved Domains (1) summary
      cd15298
      Location:32463
      7tmA_mAChR_M4; muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      98349080..98356821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)