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    ING5 inhibitor of growth family member 5 [ Homo sapiens (human) ]

    Gene ID: 84289, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ING5provided by HGNC
    Official Full Name
    inhibitor of growth family member 5provided by HGNC
    Primary source
    HGNC:HGNC:19421
    See related
    Ensembl:ENSG00000168395 MIM:608525; AllianceGenome:HGNC:19421
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p28ING5
    Summary
    This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 3.6), skin (RPKM 3.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ING5 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241687020..241729478)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (242190352..242233501)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242626435..242668893)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242576729-242577656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242578056-242578589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242584167-242584667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242584739-242585240 Neighboring gene autophagy related 4B cysteine peptidase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242596891-242597666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242600039-242600540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242600541-242601040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242604899-242605504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242607599-242608100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242608101-242608600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12553 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242626177-242626439 Neighboring gene deoxythymidylate kinase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242640872-242641704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242641943-242642572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17431 Neighboring gene D-2-hydroxyglutarate dehydrogenase Neighboring gene MPRA-validated peak4107 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242703699-242704312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242710178-242711090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242714429-242715049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242716291-242716911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242716912-242717532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242717533-242718152 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:242727152-242728351 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene CEB1 minisatellite repeat instability region

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer. Zhang F, et al. Oncotarget, 2015 Jun 30. PMID 25938545, Free PMC Article
    2. [Nucleocytoplasmic translocation of ING5 protein in breast cancer and its correlation with poor clinicopathological characteristics of breast cancer]. Song Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2018 Jan. PMID 29595458
    3. Tumor-specific mutation and downregulation of ING5 detected in oral squamous cell carcinoma. Cengiz B, et al. Int J Cancer, 2010 Nov 1. PMID 20131318
    4. ING5 is a Potential Target for Osteosarcoma Therapy. Zhang X, et al. Technol Cancer Res Treat, 2018 Jan 1. PMID 29528777, Free PMC Article
    5. Overexpression of ING5 inhibits HGF-induced proliferation, invasion and EMT in thyroid cancer cells via regulation of the c-Met/PI3K/Akt signaling pathway. Gao W, et al. Biomed Pharmacother, 2018 Feb. PMID 29272787

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
      Title: ING5 overexpression upregulates miR-34c-5p/Snail1 to inhibit EMT and invasion of lung cancer cells.
    2. Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
      Title: Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.
    3. ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
      Title: ING5 Inhibits Migration and Invasion of Esophageal Cancer Cells by Downregulating the IL-6/CXCL12 Signaling Pathway.
    4. MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
      Title: MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer.
    5. LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
      Title: LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.
    6. The data suggest that miR-376c-3p downregulated ING5 to exert protective effects against oxygen-glucose deprivation-induced cell injury in cultured human and rat cells.
      Title: Upregulation of miR-376c-3p alleviates oxygen-glucose deprivation-induced cell injury by targeting ING5.
    7. ING5 forms homodimers through its N-terminal domain, which folds independently into an elongated coiled-coil structure.
      Title: The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
    8. Results show that ING5 overexpression promotes phosphorylation-dependent degradation of beta-catenin, leading to downregulated Wnt/beta- catenin signaling and inhibition of lung cancer invasion and epithelial-mesenchymal transition.
      Title: ING5 inhibits lung cancer invasion and epithelial-mesenchymal transition by inhibiting the WNT/β-catenin pathway.
    9. The Hepatitis B virus X protein (HBx) downregulates the expression of the miR-181b target gene ING5, resulting in the promotion of HCC cell proliferation.
      Title: Hepatitis B virus X protein promotes proliferation of hepatocellular carcinoma cells by upregulating miR-181b by targeting ING5.
    10. our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis
      Title: ING5 is a Potential Target for Osteosarcoma Therapy.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23842, AC133528.2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330161.2 → NP_001317090.1  inhibitor of growth protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate promoter and differs in the 3' exon structure, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is longer than isoform 1.
      Source sequence(s)
      AC114730, AC133528
      Consensus CDS
      CCDS82585.1
      UniProtKB/TrEMBL
      A0A1B0GW41
      Related
      ENSP00000490767.1, ENST00000636051.1

    2. NM_001330162.2 → NP_001317091.1  inhibitor of growth protein 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' terminal exon compared to variant 1. The encoded isoform (3) has a shorter C-terminus than isoform 1.
      Source sequence(s)
      AC114730, AC133528, BC005370
      Consensus CDS
      CCDS82586.1
      UniProtKB/Swiss-Prot
      Q8WYH8
      Related
      ENSP00000385937.1, ENST00000406941.5
      Conserved Domains (2) summary
      cd15586
      Location:188 → 226
      PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
      cd16863
      Location:12 → 104
      ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

    3. NM_032329.6 → NP_115705.2  inhibitor of growth protein 5 isoform 1

      See identical proteins and their annotated locations for NP_115705.2

      Status: REVIEWED

      Source sequence(s)
      AC133528, AF189286, AI701412, AK074422, AK128322, BC039028, BI962551, BQ187350
      Consensus CDS
      CCDS33425.1
      UniProtKB/Swiss-Prot
      A8K1P3, Q53NU6, Q57Z54, Q8WYH8, Q9BS30
      Related
      ENSP00000322142.7, ENST00000313552.11
      Conserved Domains (2) summary
      cd15685
      Location:187 → 235
      PHD_ING5; PHD finger found in inhibitor of growth protein 5 (ING5)
      cd16863
      Location:12 → 104
      ING_ING5; Inhibitor of growth (ING) domain of inhibitor of growth protein 5 (ING5)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241687020..241729478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446012.1 → XP_047301968.1  inhibitor of growth protein 5 isoform X5

    2. XM_047446014.1 → XP_047301970.1  inhibitor of growth protein 5 isoform X7

    3. XM_047446013.1 → XP_047301969.1  inhibitor of growth protein 5 isoform X6

    4. XM_017005102.3 → XP_016860591.1  inhibitor of growth protein 5 isoform X8

      UniProtKB/TrEMBL
      B7Z6R2
      Conserved Domains (1) summary
      pfam12998
      Location:6 → 105
      ING; Inhibitor of growth proteins N-terminal histone-binding

    5. XM_047446011.1 → XP_047301967.1  inhibitor of growth protein 5 isoform X4

      UniProtKB/TrEMBL
      B7Z6R2
      Related
      ENST00000482774.5

    6. XM_017005098.2 → XP_016860587.1  inhibitor of growth protein 5 isoform X3

    7. XM_017005097.2 → XP_016860586.1  inhibitor of growth protein 5 isoform X2

    8. XM_047446010.1 → XP_047301966.1  inhibitor of growth protein 5 isoform X1

    RNA

    1. XR_007082548.1 RNA Sequence

    2. XR_007082549.1 RNA Sequence

    3. XR_007082550.1 RNA Sequence

    4. XR_007082546.1 RNA Sequence

    5. XR_007082547.1 RNA Sequence

    6. XR_007082544.1 RNA Sequence

    7. XR_007082545.1 RNA Sequence

    8. XR_007082543.1 RNA Sequence

    9. XR_002959351.2 RNA Sequence

    10. XR_007082542.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      242190352..242233501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344182.1 → XP_054200157.1  inhibitor of growth protein 5 isoform X5

    2. XM_054344184.1 → XP_054200159.1  inhibitor of growth protein 5 isoform X7

    3. XM_054344183.1 → XP_054200158.1  inhibitor of growth protein 5 isoform X6

    4. XM_054344185.1 → XP_054200160.1  inhibitor of growth protein 5 isoform X8

      UniProtKB/TrEMBL
      B7Z6R2

    5. XM_054344181.1 → XP_054200156.1  inhibitor of growth protein 5 isoform X4

      UniProtKB/TrEMBL
      B7Z6R2

    6. XM_054344180.1 → XP_054200155.1  inhibitor of growth protein 5 isoform X3

    7. XM_054344179.1 → XP_054200154.1  inhibitor of growth protein 5 isoform X2

    8. XM_054344178.1 → XP_054200153.1  inhibitor of growth protein 5 isoform X1

    RNA

    1. XR_008486553.1 RNA Sequence

    2. XR_008486554.1 RNA Sequence

    3. XR_008486555.1 RNA Sequence

    4. XR_008486551.1 RNA Sequence

    5. XR_008486552.1 RNA Sequence

    6. XR_008486549.1 RNA Sequence

    7. XR_008486550.1 RNA Sequence

    8. XR_008486548.1 RNA Sequence

    9. XR_008486547.1 RNA Sequence

    10. XR_008486546.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYH8.1 GenPept UniProtKB/Swiss-Prot:Q8WYH8

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