gfap glial fibrillary acidic protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gfapprovided by ZNC
Official Full Name: glial fibrillary acidic proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990914-3
See related: Ensembl:ENSDARG00000025301 AllianceGenome:ZFIN:ZDB-GENE-990914-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb345; gfapl; wu:fb34h11; wu:fk42c12; zgc:110485; etID36982.3; xx:af506734
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament organization and regulation of chaperone-mediated autophagy. Located in cytoplasm and type III intermediate filament. Is expressed in several structures, including anterior neural keel; nervous system; neural tube; neuronal stem cell; and optic vesicle. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (31792556..31804481, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (31660727..31673094, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aggregation-prone GFAP mutation in Alexander disease was validated using a zebrafish model; The p.Asp128Asn GFAP mutation is likely to be a disease-causing mutation
Title: Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model.
The distribution of GFAP immunoreactivity implies that enteric glia are widespread in the fish gastrointestinal tract.
Title: Glial cells revealed by GFAP immunoreactivity in fish gut.
Cells expressing the two reporters display radial glial morphology, colocalize with the NSC marker Sox2, undergo proliferation, and are capable of self-renewal within the matrix of distinct thickness in the telencephalon.
Title: gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain.
Generation of transgenic zebrafish that express green fluorescent protein (GFP) in glial cells driven by the zebrafish glial fibrillary acidic protein (GFAP) regulatory elements.
Title: GFAP transgenic zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

AI436945 (e-PCR)
- UniSTS:206604

fa12h10.s1 (e-PCR)
- UniSTS:202358

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chaperone-mediated autophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in type III intermediate filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glial fibrillary acidic protein

Names: zrf-1 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131373.2 → NP_571448.2 glial fibrillary acidic protein

See identical proteins and their annotated locations for NP_571448.2

Status: PROVISIONAL

Source sequence(s)

BC091942

UniProtKB/Swiss-Prot

A2VCX6, Q58EE9, Q5YLV6, Q6NUV9, Q6TH89, Q7T2N9, Q9PW34

UniProtKB/TrEMBL

B2GP50

Related

ENSDARP00000029607.6, ENSDART00000028270.7

Conserved Domains (2) summary

pfam00038
Location:80 → 388

Filament; Intermediate filament protein

pfam04732
Location:5 → 79

Filament_head; Intermediate filament head (DNA binding) region