cpox coproporphyrinogen oxidase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpoxprovided by ZNC
Official Full Name: coproporphyrinogen oxidaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9884
See related: Ensembl:ENSDARG00000062025 AllianceGenome:ZFIN:ZDB-GENE-030131-9884
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cpo; cb535; sb:cb535; im:7156501; wu:fc43a01
Summary: Predicted to enable coproporphyrinogen oxidase activity. Acts upstream of or within hemoglobin biosynthetic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in hematopoietic system; kidney; mesoderm; presumptive blood; and ventral mesenchyme. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (18601704..18613987, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (18565992..18582923, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables coproporphyrinogen oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables coproporphyrinogen oxidase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemoglobin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

NP_001035183.2

EC 1.3.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.