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    aktip akt interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 378716, updated on 9-Dec-2024

    Summary

    Official Symbol
    aktipprovided by ZNC
    Official Full Name
    akt interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030909-5
    See related
    Ensembl:ENSDARG00000026862 AllianceGenome:ZFIN:ZDB-GENE-030909-5
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fts; cb798; zgc:77699
    Summary
    Predicted to enable NEDD8 transferase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein neddylation. Predicted to act upstream of or within apoptotic process and protein transport. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of FHF complex. Predicted to be active in cytosol and nucleus. Is expressed in mesoderm; myotome; notochord; pronephric duct; and somite. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See aktip in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (36467314..36483796)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (36195837..36212319)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene FTO alpha-ketoglutarate dependent dioxygenase Neighboring gene uncharacterized LOC137496183 Neighboring gene nucleolar protein 58-like Neighboring gene uncharacterized LOC103911400 Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene uncharacterized LOC103911399

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of FHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AKT-interacting protein
    Names
    fused toes homolog
    fused toes protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320324.1NP_001307253.1  AKT-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the protein.
      Source sequence(s)
      CR318585, EH442845
      UniProtKB/Swiss-Prot
      Q6P3I9, Q7ZYX1
      Related
      ENSDARP00000123202.2, ENSDART00000138893.4
      Conserved Domains (2) summary
      smart00212
      Location:80222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:80220
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    2. NM_001320326.1NP_001307255.1  AKT-interacting protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR318585
      UniProtKB/Swiss-Prot
      Q6P3I9, Q7ZYX1
      Related
      ENSDARP00000122322.1, ENSDART00000146202.4
      Conserved Domains (2) summary
      smart00212
      Location:80222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:80220
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_135206.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' most exon and uses an alternate splice site in the penultimate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC063971, CR318585

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      36467314..36483796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222190.1XP_068078291.1  AKT-interacting protein isoform X1

    2. XM_005168969.5XP_005169026.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_005169026.1

      UniProtKB/Swiss-Prot
      Q7ZYX1
      Related
      ENSDARP00000029595.6, ENSDART00000029565.8
      Conserved Domains (2) summary
      smart00212
      Location:80222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:80220
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394700.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      379189..394722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)