U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pfkfb2a 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 393983, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    pfkfb2aprovided by ZNC
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-966
    See related
    Ensembl:ENSDARG00000023840 AllianceGenome:ZFIN:ZDB-GENE-040426-966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pfkfb2; zgc:56282
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pfkfb2a in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (42765530..42810726, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (42872936..42918136, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450 2J4 Neighboring gene si:ch73-217n20.1 Neighboring gene myosin, light chain 9a, regulatory Neighboring gene discs, large (Drosophila) homolog-associated protein 4a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Fei F, et al. Sheng Li Xue Bao, 2017 Feb 25. PMID 28217809
    2. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    3. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC56282

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a
    Names
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
    NP_957302.1
    XP_005170627.1
    XP_009295400.1
    XP_021325442.1
    XP_068072812.1
    XP_068072813.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201008.1 → NP_957302.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a

      See identical proteins and their annotated locations for NP_957302.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050514
      UniProtKB/TrEMBL
      Q7ZU78
      Related
      ENSDARP00000093104.4, ENSDART00000102328.5
      Conserved Domains (3) summary
      pfam00300
      Location:243 → 426
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:17 → 240
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:31 → 186
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      42765530..42810726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216712.1 → XP_068072813.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M3ANB0, F1R374

    2. XM_005170570.5 → XP_005170627.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a isoform X1

      See identical proteins and their annotated locations for XP_005170627.1

      UniProtKB/TrEMBL
      A0A8M3ANB0, F1R374
      Conserved Domains (3) summary
      pfam00300
      Location:243 → 426
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:17 → 240
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:31 → 186
      AAA_33; AAA domain

    3. XM_009297125.4 → XP_009295400.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a isoform X1

      See identical proteins and their annotated locations for XP_009295400.1

      UniProtKB/TrEMBL
      A0A8M3ANB0, F1R374
      Conserved Domains (3) summary
      pfam00300
      Location:243 → 426
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:17 → 240
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:31 → 186
      AAA_33; AAA domain

    4. XM_068216711.1 → XP_068072812.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M3ANB0, F1R374

    5. XM_021469767.2 → XP_021325442.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M9P521
      Conserved Domains (2) summary
      pfam01591
      Location:1 → 216
      6PF2K; 6-phosphofructo-2-kinase
      pfam00300
      Location:219 → 402
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous