sec24a SEC24 homolog A, COPII coat complex component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sec24aprovided by ZNC
Official Full Name: SEC24 homolog A, COPII coat complex componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-120926-1
See related: Ensembl:ENSDARG00000104375 AllianceGenome:ZFIN:ZDB-GENE-120926-1
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular protein transport. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SEC24A (SEC24 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (45685657..45709771)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (45597749..45622077, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein transport protein Sec24A

Names: SEC24 family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

45685657..45709771

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001340672.8 → XP_001340708.3 protein transport protein Sec24A isoform X1

UniProtKB/TrEMBL

A0A8M1PSG8

Conserved Domains (6) summary

COG5028
Location:256 → 1088

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:504 → 747

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:968 → 1035

Gelsolin; Gelsolin repeat

pfam04810
Location:431 → 467

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:847 → 941

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:748 → 832

Sec23_BS; Sec23/Sec24 beta-sandwich domain
XM_005170340.5 → XP_005170397.1 protein transport protein Sec24A isoform X2

UniProtKB/TrEMBL

A0A0R4ICL5, A0A8M2BHP1

Related

ENSDARP00000130391.1, ENSDART00000160530.2

Conserved Domains (6) summary

COG5028
Location:255 → 1087

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:503 → 746

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:967 → 1034

Gelsolin; Gelsolin repeat

pfam04810
Location:430 → 466

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:846 → 940

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:747 → 831

Sec23_BS; Sec23/Sec24 beta-sandwich domain