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    dlc1 DLC1 Rho GTPase activating protein [ Danio rerio (zebrafish) ]

    Gene ID: 567965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dlc1provided by ZNC
    Official Full Name
    DLC1 Rho GTPase activating proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-130206-12
    See related
    Ensembl:ENSDARG00000079317 AllianceGenome:ZFIN:ZDB-GENE-130206-12
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable GTPase activator activity and lipid binding activity. Predicted to act upstream of or within lipid transport and signal transduction. Predicted to be located in focal adhesion and membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dlc1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (15291025..15535544, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (14604512..14849057, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene phosphatidylinositol 4-kinase type 2 beta Neighboring gene uncharacterized LOC137495478 Neighboring gene uncharacterized LOC137495477 Neighboring gene sarcoglycan zeta Neighboring gene uncharacterized LOC137495479

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DLC1 Rho GTPase activating protein; rho GTPase-activating protein 7
    Names
    unm_sa1141

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      15291025..15535544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355991.3 → XP_017211480.1  rho GTPase-activating protein 7 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z677

    2. XM_021476167.2 → XP_021331842.2  rho GTPase-activating protein 7 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PK49

    3. XM_005159860.4 → XP_005159917.1  rho GTPase-activating protein 7 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B6R6, A0A8M9PK49, E7FBY0
      Related
      ENSDARP00000103088.2, ENSDART00000109970.4
      Conserved Domains (4) summary
      cd09538
      Location:9 → 68
      SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily
      smart00454
      Location:9 → 68
      SAM; Sterile alpha motif
      cd04375
      Location:679 → 900
      RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
      cl14643
      Location:931 → 1126
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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