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    mtrex Mtr4 exosome RNA helicase [ Danio rerio (zebrafish) ]

    Gene ID: 406795, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mtrexprovided by ZNC
    Official Full Name
    Mtr4 exosome RNA helicaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2854
    See related
    Ensembl:ENSDARG00000013457 AllianceGenome:ZFIN:ZDB-GENE-040426-2854
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    skiv2l2; zgc:63838; wu:fd11a05
    Summary
    Predicted to enable RNA helicase activity. Acts upstream of or within fin regeneration and positive regulation of cell division. Predicted to be located in nucleus. Predicted to be part of TRAMP complex. Is expressed in blastomere; nervous system; and pectoral fin. Orthologous to human MTREX (Mtr4 exosome RNA helicase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mtrex in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (8197849..8266094)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (8239149..8307394)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 29 Neighboring gene phospholipid phosphatase 1a Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1a Neighboring gene hydrogen voltage-gated channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern. Hultman KA, et al. Dev Biol, 2010 Jan 15. PMID 19931238, Free PMC Article
    2. Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish. Yang CT, et al. PLoS Genet, 2007 Jun. PMID 17542649, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exosome RNA helicase MTR4
    Names
    julie
    superkiller viralicidic activity 2-like 2
    NP_999933.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214768.1 → NP_999933.1  exosome RNA helicase MTR4

      See identical proteins and their annotated locations for NP_999933.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061456
      UniProtKB/TrEMBL
      Q6P7X6
      Related
      ENSDARP00000024380.7, ENSDART00000026244.9
      Conserved Domains (5) summary
      smart00490
      Location:433 → 521
      HELICc; helicase superfamily c-terminal domain
      COG4581
      Location:15 → 1034
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:130 → 275
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:860 → 1027
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:577 → 832
      rRNA_proc-arch; rRNA-processing arch domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      8197849..8266094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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