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    net1 neuroepithelial cell transforming 1 [ Danio rerio (zebrafish) ]

    Gene ID: 493607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    net1provided by ZNC
    Official Full Name
    neuroepithelial cell transforming 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041121-18
    See related
    Ensembl:ENSDARG00000032765 AllianceGenome:ZFIN:ZDB-GENE-041121-18
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92121; wu:fb13g03; wu:fb25c11
    Summary
    Enables transcription coactivator activity. Acts upstream of or within dorsal/ventral axis specification; mesendoderm development; and regulation of nodal signaling pathway. Is active in nucleus. Is expressed in axial mesoderm; margin; and shield. Orthologous to human NET1 (neuroepithelial cell transforming 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See net1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (11573552..11603169, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (11574703..11581932, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box containing 13a, tandem duplicate 1 Neighboring gene ankyrin repeat and SOCS box containing 13a, tandem duplicate 2 Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29a-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A GEF activity-independent function for nuclear Net1 in Nodal signal transduction and mesendoderm formation. Wei S, et al. J Cell Sci, 2017 Sep 15. PMID 28778986
    2. Prepatterning of developmental gene expression by modified histones before zygotic genome activation. Lindeman LC, et al. Dev Cell, 2011 Dec 13. PMID 22137762
    3. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
    4. Genome-wide RNA Tomography in the zebrafish embryo. Junker JP, et al. Cell, 2014 Oct 23. PMID 25417113
    5. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. Liu Z, et al. J Biol Chem, 2011 Aug 12. PMID 21669877, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nuclear Net1 is critical for zebrafish mesendoderm formation and Nodal signal transduction.
      Title: A GEF activity-independent function for nuclear Net1 in Nodal signal transduction and mesendoderm formation.
    2. Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
      Title: The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mesendoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of nodal signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of nodal signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of nodal signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuroepithelial cell-transforming gene 1 protein
    Names
    neuroepithelial cell transforming gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007767.1 → NP_001007768.1  neuroepithelial cell-transforming gene 1 protein

      See identical proteins and their annotated locations for NP_001007768.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085638
      UniProtKB/TrEMBL
      Q5RKM4
      Related
      ENSDARP00000049065.4, ENSDART00000049066.6
      Conserved Domains (3) summary
      smart00325
      Location:123 → 299
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam00169
      Location:332 → 446
      PH; PH domain
      cl17171
      Location:313 → 446
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      11573552..11603169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475011.2 → XP_021330686.1  neuroepithelial cell-transforming gene 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q5V8
      Conserved Domains (2) summary
      smart00325
      Location:177 → 353
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:367 → 500
      PH-like; Pleckstrin homology-like domain

    2. XM_021475012.2 → XP_021330687.1  neuroepithelial cell-transforming gene 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8M9PH78, Q5RHT9
      Related
      ENSDARP00000011006.6, ENSDART00000002682.8
      Conserved Domains (2) summary
      smart00325
      Location:152 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:342 → 475
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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