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    abraa actin binding Rho activating protein a [ Danio rerio (zebrafish) ]

    Gene ID: 324520, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abraaprovided by ZNC
    Official Full Name
    actin binding Rho activating protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120730-1
    See related
    Ensembl:ENSDARG00000038583 AllianceGenome:ZFIN:ZDB-GENE-120730-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb55a04; wu:fb55a04; wu:fc31e07
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within blood circulation and heart development. Predicted to be active in sarcomere. Is expressed in central nervous system; heart; mandibular arch skeleton; pectoral fin; and somite. Orthologous to human ABRA (actin binding Rho activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See abraa in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (52064247..52072829)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (52064249..52070258)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene R-spondin 4 Neighboring gene angiopoietin 4 Neighboring gene uncharacterized LOC137496026 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. STARS is essential to maintain cardiac development and function in vivo via a SRF pathway. Chong NW, et al. PLoS One, 2012. PMID 22815879, Free PMC Article
    2. Identification of the 14-3-3 β/α-A protein as a novel maternal peptidoglycan-binding protein that protects embryos of zebrafish against bacterial infections. Wang X, et al. Dev Comp Immunol, 2021 Jan. PMID 32931839
    3. The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish. Lai JKH, et al. Development, 2018 May 17. PMID 29773645
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood circulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding Rho-activating protein; uncharacterized protein LOC324520
    Names
    STARS

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      52064247..52072829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_694448.9 → XP_699540.2  actin-binding Rho-activating protein

      UniProtKB/TrEMBL
      A0A8N7UW36
      Related
      ENSDARP00000129512.1, ENSDART00000153468.2
      Conserved Domains (1) summary
      pfam14705
      Location:270 → 344
      Costars; Costars
    Nucleotide Protein
    Heading Accession and Version

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