hspa4b heat shock protein 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspa4bprovided by ZNC
Official Full Name: heat shock protein 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6018
See related: Ensembl:ENSDARG00000018989 AllianceGenome:ZFIN:ZDB-GENE-030131-6018
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hspa4; zgc:55743; zgc:77413; wu:fi30e11
Summary: Predicted to enable adenyl-nucleotide exchange factor activity. Predicted to be involved in protein folding. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; head; liver; neural rod; and pectoral fin bud. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (23687745..23708159)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (23390500..23410914)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of hspa4a and hspa4b are up-regulated in the inflamed gut in a manner similar to that previously observed in mammals.
Title: Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation.

Submit: New GeneRIF Correction

General gene information

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Markers

fi30e11.x1 (e-PCR)
- UniSTS:197247

fb81d05.y1 (e-PCR)
- UniSTS:191619

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock 70 kDa protein 4b

Names: heat shock protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.