sh3bgrl SH3 domain binding glutamate-rich protein like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sh3bgrlprovided by ZNC
Official Full Name: SH3 domain binding glutamate-rich protein likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1376
See related: Ensembl:ENSDARG00000058302 AllianceGenome:ZFIN:ZDB-GENE-040426-1376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:64130
Summary: Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; notochord; otic vesicle; and tail bud. Orthologous to human SH3BGRL (SH3 domain binding glutamate rich protein like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (9405099..9420887, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (9099085..9114873, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish.
Title: Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk30g07.y1 (e-PCR)
- UniSTS:200785

fc30c04.x1 (e-PCR)
- UniSTS:193482

fc25b11.y1 (e-PCR)
- UniSTS:193242

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH3 domain-binding glutamic acid-rich-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201209.1 → NP_957503.1 SH3 domain-binding glutamic acid-rich-like protein

See identical proteins and their annotated locations for NP_957503.1

Status: PROVISIONAL

Source sequence(s)

BC054623

UniProtKB/TrEMBL

Q6TLE2, Q7T2A8

Related

ENSDARP00000075601.4, ENSDART00000081158.5

Conserved Domains (1) summary

cd03030
Location:2 → 97

GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...