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    palb2 partner and localizer of BRCA2 [ Danio rerio (zebrafish) ]

    Gene ID: 558923, updated on 4-Jan-2025

    Summary

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    Official Symbol
    palb2provided by ZNC
    Official Full Name
    partner and localizer of BRCA2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090313-43
    See related
    AllianceGenome:ZFIN:ZDB-GENE-090313-43
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Fancn; si:ch211-14k19.9
    Summary
    Predicted to enable DNA binding activity. Predicted to act upstream of or within double-strand break repair via homologous recombination. Is expressed in brain; eye; immature eye; lens; and pectoral fin fold. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; female breast cancer; hereditary breast ovarian cancer syndrome; and pancreatic cancer. Orthologous to human PALB2 (partner and localizer of BRCA2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See palb2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (9124996..9134055, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (8440879..8449953, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:ch211-14k19.8 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1a Neighboring gene uncharacterized LOC110439775 Neighboring gene RASD family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Fanconi anemia/BRCA gene network in zebrafish: embryonic expression and comparative genomics. Titus TA, et al. Mutat Res, 2009 Jul 31. PMID 19101574, Free PMC Article
    2. Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. Ramanagoudr-Bhojappa R, et al. PLoS Genet, 2018 Dec. PMID 30540754, Free PMC Article
    3. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    partner and localizer of BRCA2
    Names
    Fanconi N
    Fanconi anemia
    complementation group N

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      9124996..9134055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001919731.8 → XP_001919766.3  partner and localizer of BRCA2

      UniProtKB/TrEMBL
      A0A8M1QKC3
      Conserved Domains (2) summary
      pfam12958
      Location:18 → 50
      DUF3847; Protein of unknown function (DUF3847)
      pfam16756
      Location:961 → 1290
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394461.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      233261..242059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471112.2 → XP_021326787.1  partner and localizer of BRCA2

      UniProtKB/TrEMBL
      A0A8M9P7S0
      Conserved Domains (2) summary
      pfam12958
      Location:18 → 50
      DUF3847; Protein of unknown function (DUF3847)
      pfam16756
      Location:948 → 1271
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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