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    plxnc1 plexin C1 [ Danio rerio (zebrafish) ]

    Gene ID: 562273, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plxnc1provided by ZNC
    Official Full Name
    plexin C1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1620
    See related
    AllianceGenome:ZFIN:ZDB-GENE-030131-1620
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb76c04; wu:fb76c04; si:dkeyp-90a8.2
    Summary
    Predicted to enable semaphorin receptor activity. Predicted to be involved in axon guidance. Predicted to act upstream of or within semaphorin-plexin signaling pathway. Predicted to be located in membrane. Orthologous to human PLXNC1 (plexin C1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plxnc1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18282646..18317568, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18293670..18328635, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1B Neighboring gene bridge-like lipid transfer protein family member 3B Neighboring gene uncharacterized LOC103910448 Neighboring gene uncharacterized LOC137491542 Neighboring gene plexin-C1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin. Wang Y, et al. Elife, 2013 Oct 1. PMID 24137545, Free PMC Article
    2. Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Kolb J, et al. Nat Commun, 2023 Oct 26. PMID 37884489, Free PMC Article
    3. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin c1 has been described.
      Title: Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables semaphorin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within semaphorin-plexin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    plexin-C1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      18282646..18317568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068220763.1 → XP_068076864.1  plexin-C1 isoform X2

    2. XM_021475249.2 → XP_021330924.1  plexin-C1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ARP5
      Conserved Domains (4) summary
      pfam01437
      Location:393 → 430
      PSI; Plexin repeat
      pfam01833
      Location:587 → 673
      TIG; IPT/TIG domain
      pfam08337
      Location:923 → 1447
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      cl15693
      Location:75 → 391
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    Nucleotide Protein
    Heading Accession and Version

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