uevld UEV and lactate/malate dehyrogenase domains [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uevldprovided by ZNC
Official Full Name: UEV and lactate/malate dehyrogenase domainsprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-138
See related: Ensembl:ENSDARG00000009266 AllianceGenome:ZFIN:ZDB-GENE-040801-138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb14b11; zgc:100959
Summary: Predicted to enable ubiquitin binding activity. Predicted to be involved in endosome to lysosome transport. Predicted to act upstream of or within carboxylic acid metabolic process; protein modification process; and protein transport. Predicted to be part of ESCRT I complex. Orthologous to human UEVLD (UEV and lactate/malate dehyrogenase domains). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (24181072..24202655, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (24083519..24105107, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc87h04.y1 (e-PCR)
- UniSTS:194718

fb14b11.x1 (e-PCR)
- UniSTS:190126

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 variant 3

Names: EV and lactate/malate dehydrogenase domain-containing protein; UEV-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003619.2 → NP_001003619.1 ubiquitin-conjugating enzyme E2 variant 3

See identical proteins and their annotated locations for NP_001003619.1

Status: PROVISIONAL

Source sequence(s)

BC078313

UniProtKB/Swiss-Prot

Q6DBY5

UniProtKB/TrEMBL

A0A8M9PYC4

Related

ENSDARP00000048506.4, ENSDART00000048507.5

Conserved Domains (3) summary

cd05293
Location:172 → 468

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:179 → 460

L-LDH-NAD; L-lactate dehydrogenase

pfam05743
Location:21 → 139

UEV; UEV domain