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    lamp2 lysosomal-associated membrane protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 541406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lamp2provided by ZNC
    Official Full Name
    lysosomal-associated membrane protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030729-9
    See related
    Ensembl:ENSDARG00000014914 AllianceGenome:ZFIN:ZDB-GENE-030729-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb587; wu:fb14a06; zgc:103532
    Summary
    Acts upstream of or within macroautophagy. Predicted to be located in lysosome and membrane. Predicted to be active in bounding membrane of organelle and plasma membrane. Is expressed in cardiovascular system; heart; solid lens vesicle; vein; and yolk syncytial layer. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lamp2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33472790..33481527, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33132476..33141271, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 33 Neighboring gene transmembrane protein 255A Neighboring gene ATPase Na+/K+ transporting subunit beta 4 Neighboring gene cullin 4B Neighboring gene MCTS1 re-initiation and release factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy. Dvornikov AV, et al. J Mol Cell Cardiol, 2019 Aug. PMID 31228518, Free PMC Article
    2. Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. Rodríguez-Fraticelli AE, et al. Nat Cell Biol, 2015 Mar. PMID 25706235, Free PMC Article
    3. Inhibited Lipophagy Suppresses Lipid Metabolism in Zebrafish Liver Cells. Wang J, et al. Front Physiol, 2019. PMID 31496957, Free PMC Article
    4. Starvation stress affects the maternal development and larval fitness in zebrafish (Danio rerio). Fan X, et al. Sci Total Environ, 2019 Dec 10. PMID 31425978
    5. A lysosomal regulatory circuit essential for the development and function of microglia. Iyer H, et al. Sci Adv, 2022 Sep 2. PMID 36044568, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosome-associated membrane glycoprotein 2
    Names
    lysosomal membrane glycoprotein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013533.1 → NP_001013551.1  lysosome-associated membrane glycoprotein 2 precursor

      See identical proteins and their annotated locations for NP_001013551.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090897
      UniProtKB/TrEMBL
      A0A8M1N4L3, Q5BKX3
      Related
      ENSDARP00000105565.2, ENSDART00000124242.4
      Conserved Domains (1) summary
      pfam01299
      Location:113 → 355
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      33472790..33481527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291116.4 → XP_009289391.1  lysosome-associated membrane glycoprotein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IZ00, A0A8M3AP77
      Related
      ENSDARP00000141125.2, ENSDART00000164836.2
      Conserved Domains (1) summary
      pfam01299
      Location:113 → 356
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    2. XM_021481012.2 → XP_021336687.1  lysosome-associated membrane glycoprotein 2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q0I4, A0A8M9PZ65
      Related
      ENSDARP00000146649.1, ENSDART00000186833.1
      Conserved Domains (1) summary
      pfam01299
      Location:113 → 357
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    Nucleotide Protein Strain
    Heading Accession and Version

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