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    pah phenylalanine hydroxylase [ Danio rerio (zebrafish) ]

    Gene ID: 378962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pahprovided by ZNC
    Official Full Name
    phenylalanine hydroxylaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031006-2
    See related
    Ensembl:ENSDARG00000020143 AllianceGenome:ZFIN:ZDB-GENE-031006-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb877; zgc:65981; wu:fb02f10
    Summary
    Predicted to enable phenylalanine 4-monooxygenase activity. Acts upstream of or within cellular response to estrogen stimulus. Is expressed in several structures, including digestive system; epidermis; eye; optic vesicle; and periderm. Human ortholog(s) of this gene implicated in intellectual disability and phenylketonuria. Orthologous to human PAH (phenylalanine hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pah in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17391680..17409367, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17402704..17420391, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 37 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone Neighboring gene tyrosine hydroxylase 2 Neighboring gene uncharacterized LOC101884203 Neighboring gene achaete-scute family bHLH transcription factor 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Forward genetic analysis of visual behavior in zebrafish. Muto A, et al. PLoS Genet, 2005 Nov. PMID 16311625, Free PMC Article
    2. Two tyrosine hydroxylase genes in teleosts. Candy J, et al. Biochim Biophys Acta, 2005 Jan 21. PMID 15652156
    3. Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. Ren G, et al. J Biol Chem, 2013 Aug 2. PMID 23754283, Free PMC Article
    4. The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Fu J, et al. Ecotoxicol Environ Saf, 2020 Feb. PMID 31830605
    5. Transcriptome profiling of zebrafish infected with Streptococcus suis. Wu Z, et al. Microb Pathog, 2010 May. PMID 20206250

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65981

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine 4-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine 4-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tyrosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phenylalanine-4-hydroxylase
    NP_956845.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200551.1 → NP_956845.1  phenylalanine-4-hydroxylase

      See identical proteins and their annotated locations for NP_956845.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056537
      UniProtKB/TrEMBL
      Q6PHI7
      Related
      ENSDARP00000012808.6, ENSDART00000011943.7
      Conserved Domains (3) summary
      TIGR01268
      Location:20 → 449
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
      cd04931
      Location:19 → 108
      ACT_PAH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, phenylalanine hydroxylases (PAH)
      pfam00351
      Location:117 → 447
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      17391680..17409367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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