ttpa tocopherol (alpha) transfer protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ttpaprovided by ZNC
Official Full Name: tocopherol (alpha) transfer proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4631
See related: Ensembl:ENSDARG00000027584 AllianceGenome:ZFIN:ZDB-GENE-030131-4631
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66361; wu:fd44e05
Summary: Predicted to enable lipid transfer activity; phosphatidylinositol bisphosphate binding activity; and vitamin E binding activity. Acts upstream of or within central nervous system development and chordate embryonic development. Predicted to be active in late endosome. Is expressed in several structures, including digestive system; immature eye; nervous system; tail bud; and yolk syncytial layer. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (26647472..26653148)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (26991838..26997514)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio).
Title: Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio).
We conclude that TTP is essential for early development of the vertebrate central nervous system.
Title: The α-tocopherol transfer protein is essential for vertebrate embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin E binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin E metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-tocopherol transfer protein

Names: tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199731.2 → NP_956025.2 alpha-tocopherol transfer protein

Status: VALIDATED

Source sequence(s)

BX248497

UniProtKB/TrEMBL

A0A8M1PFT6, B0S5J5

Related

ENSDARP00000117556.1, ENSDART00000145415.3

Conserved Domains (2) summary

smart01100
Location:26 → 70

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

pfam00650
Location:97 → 246

CRAL_TRIO; CRAL/TRIO domain