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    slc24a2 solute carrier family 24 member 2 [ Danio rerio (zebrafish) ]

    Gene ID: 751686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc24a2provided by ZNC
    Official Full Name
    solute carrier family 24 member 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-277
    See related
    Ensembl:ENSDARG00000042988 AllianceGenome:ZFIN:ZDB-GENE-060825-277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153443
    Summary
    Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport; intracellular calcium ion homeostasis; and regulation of synaptic plasticity. Predicted to act upstream of or within calcium ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in gill. Orthologous to human SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc24a2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12009651..12041477)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11322755..11354844)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene tetraspanin 5b Neighboring gene uncharacterized LOC137495449 Neighboring gene store-operated calcium entry-associated regulatory factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel K(+) -dependent Na(+) uptake mechanism during low pH exposure in adult zebrafish (Danio rerio): New tricks for old dogma. Clifford AM, et al. Acta Physiol (Oxf), 2022 Mar. PMID 34985194
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC153443

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/potassium/calcium exchanger 2-like; sodium/potassium/calcium exchanger 2-like
    Names
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328436.1 → NP_001315365.1  Sodium/potassium/calcium exchanger 2-like

      Status: VALIDATED

      Source sequence(s)
      BX908747
      UniProtKB/TrEMBL
      A0A8M1P3W8, E9QFG3
      Related
      ENSDARP00000074550.5, ENSDART00000080100.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      12009651..12041477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355745.3 → XP_017211234.1  sodium/potassium/calcium exchanger 2-like isoform X1

      UniProtKB/TrEMBL
      A0A8M6YXT0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045400.2: Suppressed sequence

      Description
      NM_001045400.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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