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    nell2b neural EGFL like 2b [ Danio rerio (zebrafish) ]

    Gene ID: 336082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nell2bprovided by ZNC
    Official Full Name
    neural EGFL like 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8026
    See related
    Ensembl:ENSDARG00000062797 AllianceGenome:ZFIN:ZDB-GENE-030131-8026
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj47f01; wu:fj47f01; si:dkey-234l24.6
    Summary
    Predicted to enable heparin binding activity and protein kinase C binding activity. Predicted to be involved in animal organ development. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm and extracellular space. Is expressed in nervous system and pharyngeal arch. Orthologous to human NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nell2b in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (14247745..14328965, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (14250137..14330116, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910420 Neighboring gene pseudouridine synthase 7 like Neighboring gene twinfilin actin-binding protein 1b Neighboring gene uncharacterized LOC137491394 Neighboring gene prolactin 2 Neighboring gene NUAK family, SNF1-like kinase, 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of nel during zebrafish embryonic development. Zhao J, et al. Gene Expr Patterns, 2022 Sep. PMID 35691514
    2. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neural EGFL like 2b; protein kinase C-binding protein NELL2a-like
    Names
    NEL-like 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      14247745..14328965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002661379.7 → XP_002661425.1  protein kinase C-binding protein NELL2a-like

      UniProtKB/TrEMBL
      A0A8M1RDG0, F1QV50
      Related
      ENSDARP00000085584.5, ENSDART00000091151.7
      Conserved Domains (6) summary
      smart00179
      Location:556 → 590
      EGF_CA; Calcium-binding EGF-like domain
      smart00214
      Location:710 → 757
      VWC; von Willebrand factor (vWF) type C domain
      pfam07645
      Location:603 → 634
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:487 → 522
      EGF_3; EGF domain
      cl17735
      Location:273 → 329
      VWC; von Willebrand factor type C domain
      cl22861
      Location:28 → 213
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Nucleotide Protein
    Heading Accession and Version

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