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    hcfc2 host cell factor C2 [ Danio rerio (zebrafish) ]

    Gene ID: 550401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hcfc2provided by ZNC
    Official Full Name
    host cell factor C2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-203
    See related
    Ensembl:ENSDARG00000058127 AllianceGenome:ZFIN:ZDB-GENE-050417-203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112202; si:ch73-376i21.2
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be part of histone methyltransferase complex. Orthologous to human HCFC2 (host cell factor C2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hcfc2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (9183657..9196304, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (9182741..9195388, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene carbohydrate (chondroitin 4) sulfotransferase 11 Neighboring gene nuclear transcription factor Y, beta a Neighboring gene arginine vasopressin receptor 1Ab Neighboring gene SLIT-ROBO Rho GTPase activating protein 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    host cell factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327839.1 → NP_001314768.1  host cell factor 2

      Status: VALIDATED

      Source sequence(s)
      FP236856
      UniProtKB/TrEMBL
      A0A8M1P8C7, X1WCP5
      Related
      ENSDARP00000127992.1, ENSDART00000153963.3
      Conserved Domains (5) summary
      cd00063
      Location:574 → 677
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:189 → 240
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:21 → 58
      Kelch_1; Kelch motif
      pfam13415
      Location:206 → 252
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:123 → 167
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      9183657..9196304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001017706.1: Suppressed sequence

      Description
      NM_001017706.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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