abcb11a ATP-binding cassette, sub-family B (MDR/TAP), member 11a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcb11aprovided by ZNC
Official Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050517-13
See related: Ensembl:ENSDARG00000011573 AllianceGenome:ZFIN:ZDB-GENE-050517-13
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc21d02; wu:fc21d02
Summary: Predicted to enable ABC-type bile acid transporter activity and canalicular bile acid transmembrane transporter activity. Predicted to be involved in canalicular bile acid transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (48752102..48816476)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (49043026..49119538)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables canalicular bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canalicular bile acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info