appb amyloid beta (A4) precursor protein b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: appbprovided by ZNC
Official Full Name: amyloid beta (A4) precursor protein bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020220-1
See related: Ensembl:ENSDARG00000055543 AllianceGenome:ZFIN:ZDB-GENE-020220-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92771; wu:fc43a03
Summary: Predicted to enable signaling receptor activator activity and signaling receptor binding activity. Acts upstream of or within several processes, including nervous system development; regulation of Notch signaling pathway; and regulation of non-motile cilium assembly. Predicted to be located in Golgi-associated vesicle and membrane. Predicted to be active in several cellular components, including Golgi apparatus; early endosome; and membrane raft. Is expressed in several structures, including axial vasculature; axis; nervous system; pronephric duct; and spinal cord neural rod. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (35026415..35069777, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (35217234..35260543, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish.
Title: The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish.
Appb-regulated neurogenesis is mediated through balancing the Notch1a signaling pathway and has roles in the development of the Mauthner cell
Title: β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner.
Decreased level of Appb affects motor neuron outgrowth and patterning.
Title: The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation.
The APPb enhancer displays tissue specificity: with its full complement of upstream regulatory elements, the expression is exclusively in neurons, but its enhancing function is restricted to the notochord when acting through its basal promoter elements.
Title: Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish.
expression pattern during embryonic development
Title: Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development.
A "CAGA" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.
Title: Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.

Submit: New GeneRIF Correction

General gene information

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Markers

fc43a03.x1 (e-PCR)
- UniSTS:193840

fc27a10.y1 (e-PCR)
- UniSTS:193346

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amyloid beta (A4) precursor protein b

Names: amyloid beta precursor protein b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152886.2 → NP_690842.2 amyloid beta (A4) precursor protein b precursor

Status: VALIDATED

Source sequence(s)

CR759841

UniProtKB/TrEMBL

Q8UUR9

Related

ENSDARP00000110143.2, ENSDART00000125536.4