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    lpin2 lipin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 558422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpin2provided by ZNC
    Official Full Name
    lipin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-153
    See related
    Ensembl:ENSDARG00000061214 AllianceGenome:ZFIN:ZDB-GENE-060503-153
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lipin2; si:dkey-216e9.8
    Summary
    Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in cytosol; endoplasmic reticulum membrane; and nucleus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN2 (lipin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lpin2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30960318..30984508)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30976745..31000975)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 12, genome duplicate 2 Neighboring gene myomesin 1a (skelemin) Neighboring gene uncharacterized LOC137487890 Neighboring gene elastin microfibril interfacer 2a Neighboring gene uncharacterized LOC137487892

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. Lordén G, et al. J Exp Med, 2017 Feb. PMID 28031477, Free PMC Article
    2. Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. Sapp V, et al. Hepatology, 2014 Nov. PMID 25043405
    3. Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. Chen B, et al. Front Endocrinol (Lausanne), 2018. PMID 30026731, Free PMC Article
    4. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate phosphatase LPIN2
    XP_005163511.1
    XP_707850.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      30960318..30984508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_702758.9 → XP_707850.4  phosphatidate phosphatase LPIN2 isoform X2

      UniProtKB/TrEMBL
      A0A8N7TC03, F1RAK9
      Related
      ENSDARP00000079677.6, ENSDART00000085242.6
      Conserved Domains (4) summary
      pfam15017
      Location:883 → 902
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:644 → 869
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:472 → 562
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. XM_005163454.5 → XP_005163511.1  phosphatidate phosphatase LPIN2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAN1
      Conserved Domains (4) summary
      pfam15017
      Location:920 → 939
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:38 → 143
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:681 → 906
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:509 → 599
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    Nucleotide Protein Strain
    Heading Accession and Version

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