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    mylk5 myosin, light chain kinase 5 [ Danio rerio (zebrafish) ]

    Gene ID: 100003770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mylk5provided by ZNC
    Official Full Name
    myosin, light chain kinase 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050309-74
    See related
    Ensembl:ENSDARG00000075164 AllianceGenome:ZFIN:ZDB-GENE-050309-74
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7148400; si:dkey-194j22.6
    Summary
    Predicted to enable myosin light chain kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in eye; head; and post-vent region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mylk5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (31662238..31699299)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (31530436..31567653)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 2 Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene coiled-coil domain containing 47 Neighboring gene ddb1 and cul4 associated factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. Lou SS, et al. J Cell Biol, 2015 Apr 27. PMID 25918227, Free PMC Article
    2. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Li J, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476374, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle structure development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain kinase, smooth muscle
    Names
    mlck

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      31662238..31699299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164056.5 → XP_005164113.1  myosin light chain kinase, smooth muscle isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBA3, F1QPV1
      Related
      ENSDARP00000097960.2, ENSDART00000113441.4
      Conserved Domains (6) summary
      cd00096
      Location:781 → 852
      Ig; Immunoglobulin domain
      smart00220
      Location:434 → 689
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:310 → 404
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:764 → 855
      I-set; Immunoglobulin I-set domain
      cd14103
      Location:440 → 689
      STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase
      cl11960
      Location:217 → 314
      Ig; Immunoglobulin domain

    2. XM_003198128.6 → XP_003198176.2  myosin light chain kinase, smooth muscle isoform X2

      UniProtKB/TrEMBL
      A0A8M1REW7
      Conserved Domains (6) summary
      cd00096
      Location:730 → 801
      Ig; Immunoglobulin domain
      smart00220
      Location:383 → 638
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:259 → 353
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:713 → 804
      I-set; Immunoglobulin I-set domain
      cd14103
      Location:389 → 638
      STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase
      cl11960
      Location:166 → 263
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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